Anti-Human/Rat/Fish AChR Antibody (Mab35) 

Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models^[1][2][3].

Rat IgG1

Rat IgG1 kappa, Isotype Control

Human/Rat/Fish

AChR

Anti-Human/Rat/Fish AChR Antibody (Mab35) (10 nM, 24 h) significantly inhibits the secretion of catecholamines in bovine adrenal chromaffin cells^[2].
Anti-Human/Rat/Fish AChR Antibody (Mab35) specifically binds to the α1, α3, and α5 subunits of nAChR in TIB-175 hybridoma cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Rat/Fish AChR Antibody (Mab35) (1 mg/kg, i.v., on the seventh day after injection of C5 siRNA/LNP) successfully constructs the myasthenia gravis (MG) model in female Lewis rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1138  [NCBI]

P30532 / NP_000736.2

EAMG induction in rats; Immunofluorescence

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Human/Rat/Fish AChR Antibody (Mab35)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kuboi Y, et al. Identification of potent siRNA targeting complement C5 and its robust activity in pre-clinical models of myasthenia gravis and collagen-induced arthritis. Mol Ther Nucleic Acids. 2023 Jan 13;31:339-351.  [Content Brief]

  [2]. Gu H, et al. Characterization and localization of adrenal nicotinic acetylcholine receptors: evidence that mAb35-nicotinic receptors are the principal receptors mediating adrenal catecholamine secretion. J Neurochem. 1996 Apr;66(4):1454-61.  [Content Brief]

  [3]. Jin L, et al. Nicotinic receptor alpha subunits in magnocellular neurons of rat hypothalamus. Neuroreport. 2004 Oct 25;15(15):2333-6.  [Content Brief]