CHRNA5 - cholinergic receptor nicotinic alpha 5 subunit Gene
Also Known as LNCR2
Species: Homo sapiens
About CHRNA5
This gene has 4 transcripts (splice variants), 199 orthologues, 45 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 1.4), colon (RPKM 1.2) and 19 other tissues.
Summary
The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung Cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
CHRNA5 Products (7)
| mRNA | Protein | Name |
|---|---|---|
| NM_000745.4 | NP_000736.2 | neuronal acetylcholine receptor subunit alpha-5 isoform 1 precursor |
| NM_001307945.2 | NP_001294874.1 | neuronal acetylcholine receptor subunit alpha-5 isoform 2 precursor |
| NM_001395171.1 | NP_001382100.1 | neuronal acetylcholine receptor subunit alpha-5 isoform 3 precursor |
| NM_001395172.1 | NP_001382101.1 | neuronal acetylcholine receptor subunit alpha-5 isoform 4 precursor |
| NM_001395173.1 | NP_001382102.1 | neuronal acetylcholine receptor subunit alpha-5 isoform 5 precursor |
| NM_001395174.1 | NP_001382103.1 | neuronal acetylcholine receptor subunit alpha-5 isoform 6 precursor |
| NM_001395175.1 | NP_001382104.1 | neuronal acetylcholine receptor subunit alpha-5 isoform 7 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables acetylcholine receptor activity |
IDA
IDA: Inferred from direct assay
|
1542648 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
8663494 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in behavioral response to nicotine |
IMP
IMP: Inferred from mutant phenotype
|
18227835 | GOA |
CHRNA5 Protein Structure
Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (47 - 249)
Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (257 - 380)
Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (376 - 447)
- 0
- 100
- 200
- 300
- 400
- 468 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
neuronal acetylcholine receptor subunit alpha-5 |
|
CHRNA5 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CHRNA5 | P30532 | CHRNB2 | Homo sapiens | P17787 | 8663494 |
Recombinant CHRNA5 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70340 | nAChRα5 Protein, Human (HEK293, His) | P30532/NP_000736.2 (R23-T254) | ≥ 90%, as determined by reducing SDS-PAGE. |
CHRNA5 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82914 | Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA2659) | WB, FC, IP | Human, Mouse, Rat |
| HY-P84248 | Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945) | WB, FC, ELISA | Human, Rat |
| HY-P84248A | Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945)(PBS only) | WB, FC, ELISA | Human, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Smoking As A Quantitative Trait Locus 3 |
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| Tobacco Addiction |
|
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| Substance Dependence |
|
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| Cocaine Dependence |
|
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| Lung Cancer |
|
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| Drug Dependence |
|
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| Autosomal Dominant Nocturnal Frontal Lobe Epilepsy |
|
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| Schizophrenia 19 |
|
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| Schizophrenia |
|
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| Alcohol Dependence |
|
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| Attention Deficit-Hyperactivity Disorder |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | CHRNA5 | MGD | MGI:87889 |
| Canis familiaris | CHRNA5 | VGNC | VGNC:49739 |
| Rattus norvegicus | CHRNA5 | RGD | RGD:2347 |
| Macaca mulatta | CHRNA5 | VGNC | VGNC:71048 |
| Felis catus | CHRNA5 | VGNC | VGNC:60882 |
| Bos taurus | CHRNA5 | VGNC | VGNC:27327 |
| Others | CHRNA5 | NCBI |