CHRNA5 - cholinergic receptor nicotinic alpha 5 subunit Gene

Also Known as LNCR2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1138

About CHRNA5

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,565,520-78,595,269 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues, 45 paralogues and is associated with 1 phenotype. Broad expression in gall bladder (RPKM 1.4), colon (RPKM 1.2) and 19 other tissues.

Summary

The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung Cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]

CHRNA5 Products (7)

mRNA Protein Name
NM_000745.4 NP_000736.2 neuronal acetylcholine receptor subunit alpha-5 isoform 1 precursor
NM_001307945.2 NP_001294874.1 neuronal acetylcholine receptor subunit alpha-5 isoform 2 precursor
NM_001395171.1 NP_001382100.1 neuronal acetylcholine receptor subunit alpha-5 isoform 3 precursor
NM_001395172.1 NP_001382101.1 neuronal acetylcholine receptor subunit alpha-5 isoform 4 precursor
NM_001395173.1 NP_001382102.1 neuronal acetylcholine receptor subunit alpha-5 isoform 5 precursor
NM_001395174.1 NP_001382103.1 neuronal acetylcholine receptor subunit alpha-5 isoform 6 precursor
NM_001395175.1 NP_001382104.1 neuronal acetylcholine receptor subunit alpha-5 isoform 7 precursor
Molecular Function GO Annotation Evidence References Source
enables acetylcholine receptor activity IDA
IDA: Inferred from direct assay
1542648 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
8663494 GOA
Biological Process GO Annotation Evidence References Source
involved in behavioral response to nicotine IMP
IMP: Inferred from mutant phenotype
18227835 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRNA5 Protein Structure

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (47 - 249)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (257 - 380)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (376 - 447)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 468 a.a.
Protein Preferred Names Protein Names

neuronal acetylcholine receptor subunit alpha-5

  • Cholinergic receptor, neuronal nicotinic, alpha polypeptide-5

CHRNA5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHRNA5 P30532 CHRNB2 Homo sapiens P17787 8663494
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CHRNA5 Proteins

Cat. No. Product Name Accession Purity
HY-P70340 nAChRα5 Protein, Human (HEK293, His) P30532/NP_000736.2 (R23-T254) ≥ 90%, as determined by reducing SDS-PAGE.

CHRNA5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82914 Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA2659) WB, FC, IP Human, Mouse, Rat
HY-P84248 Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945) WB, FC, ELISA Human, Rat
HY-P84248A Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945)(PBS only) WB, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Smoking As A Quantitative Trait Locus 3
  • Lung Cancer Susceptibility 2

  • Nicotine Dependence

  • SQTL3

  • Nicotine Dependence, Susceptibility To

Tobacco Addiction
  • Nicotine Dependence

  • Tobacco Addiction, Susceptibility To

  • Nicotine Addiction

  • Tobacco Use Disorder

  • Smoking Habit

  • Nicotine Dependence, Protection Against

  • Nicotine Addiction, Protection From

  • Cigarette Habituation

  • Cigarette Habituation, Susceptibility To

  • Smoking Habit, Susceptibility To

  • Nicotine Dependence, Susceptibility To

  • Nicotine Addiction, Susceptibility To

  • Addiction, Tobacco, Susceptibility To

  • Compulsive Tobacco User Syndrome

  • Tobacco Dependence

  • Tobacco Dependence Syndrome

  • Cigarette Addiction

  • Cigarette Dependence

  • Smoking Addiction

  • Smokers Syndrome

Substance Dependence
Cocaine Dependence
Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Drug Dependence
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
  • Adnfle

  • Autosomal Dominant Sleep-Related Hypermotor Epilepsy

  • Enfl

  • Benign Familial Infantile Seizures 6

  • Benign Familial Infantile Seizures, 6

  • Nocturnal Frontal Lobe Epilepsy-4

  • Enfl1

  • Epilepsy, Nocturnal Frontal Lobe, 1

  • Epilepsy, Nocturnal Frontal Lobe, Type 1

Schizophrenia 19
  • SCZD19

  • Schizophrenia 19 With Or Without An Affective Disorder

  • Schizophrenia 19, Susceptibility To

  • {Schizophrenia 19, Susceptibility To}

Schizophrenia
  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1

Alcohol Dependence
  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic

Attention Deficit-Hyperactivity Disorder
  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus CHRNA5 MGD MGI:87889
Canis familiaris CHRNA5 VGNC VGNC:49739
Rattus norvegicus CHRNA5 RGD RGD:2347
Macaca mulatta CHRNA5 VGNC VGNC:71048
Felis catus CHRNA5 VGNC VGNC:60882
Bos taurus CHRNA5 VGNC VGNC:27327
Others CHRNA5 NCBI