Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945)
(Synonyms: LNCR2)Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nicotinic Acetylcholine Receptor alpha 5.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, FC, ELISA
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
Nicotinic Acetylcholine Receptor alpha 5 Antibody (YA3945) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Nicotinic Acetylcholine Receptor alpha 5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 53 kDa
Purified recombinant fragment of human CHRNA5 (AA: extra 23-254) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Nicotinic Acetylcholine Receptor alpha 5 component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4. Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2. Plays a role in nicotine addiction[1][2].
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Subcellular Localization
Synaptic cell membrane; Multi-pass membrane protein; Cell membrane; Multi-pass membrane protein
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Subunit
Neuronal AChR that forms heteropentamers composed of two different type of subunits: alpha and non-alpha (beta). CHRNA5/alpha-5 subunit is only able to form functional nAChRs when co-assembled with another alpha subunit, can be combined to CHRNA4/alpha-4 or CHRNA3/alpha-3 and CHRNB4/beta-4 or CHRNB2/beta-2 to give rise to functional receptors (PubMed:20881005, PubMed:8663494). Interacts with LYPD6 (PubMed:27344019)
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SwissProt ID
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Synonyms
LNCR2
Documentation
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