Anti-Mouse PD-1 Antibody (RMP1-14)

Name: Anti-Mouse PD-1 Antibody (RMP1-14)
Brand: MedChemExpress
SKU: HY-P99144
Rating: 5.0 (24 reviews)

Cat. No.: HY-P99144 Pureté: 99.63%: Fiche technique
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Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma.

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Size	Stock	Quantité
Échantillon gratuit (100 μg)	Appliquer maintenant
Échantillon gratuit (100 μg)	Appliquer maintenant
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Based on 24 publication(s) in Google Scholar

Other Forms of Anti-Mouse PD-1 Antibody (RMP1-14):

Anti-Mouse PD-1 Antibody (S-5001) In-stock

24 Publications Citing Use of MCE Anti-Mouse PD-1 Antibody (RMP1-14)

In Vivo Efficacy Study

RT-PCR

Cell Imaging/Staining

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jan 22;189(2):418-434.e24. [Abstract]; Aslfl/flFoxp3YFP-Cre or littermate Aslwt/wtFoxp3YFP-Cre mice treated with or without Anti-PD-1 antibody (200 μg, i.p.) were subcutaneously inoculated with Hep-53.4 cells (1 × 10⁶), the tumor volume was evaluated every three days. Proportion of Tregs and ammonia levels in the subcutaneous tumors on day 18 were analyzed (n = 6).

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: Cell. 2026 Jan 22;189(2):418-434.e24. [Abstract]; Hematoxylin and eosin (H&E) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining evaluated HCC tissues from patients treated with or without PD-1 (200 μg, i.p.) therapy. Elevated tissue ammonia and increased tumor-infiltrating Tregs accordingly.

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 11;23(1):201. [Abstract]; IL-6 and TNF-α levels increased of PFC and serum in MIA offspring mice after PD-1 (1 μg/10⁶ cells, 24 h) Ab alone or PD-1 Ab + MSC-EVs administration.

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 11;23(1):201. [Abstract]; Immunostaining analysis of the level of Iba-1⁺, the microglial soma size, branch number, and total branch length were significantly increased in PD-1 Ab (1 μg/10⁶ cells, 24 h) group.

: Anti-Mouse PD-1 Antibody (RMP1-14) purchased from MedChemExpress. Usage Cited in: J Nanobiotechnology. 2025 Mar 11;23(1):201. [Abstract]; Western blot analysis p-ERK/ERK level elevated in primary microglia after PD-1 (1 μg/10⁶ cells, 24 h) Ab alone or PD-1 Ab + MSC-EVs intervention.

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Activité biologique
Pureté et documentation
Références
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Description

Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma^[1].

Isotype

Rat IgG2a kappa

Recommend Isotype Controls

Rat IgG2a kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

PD-1

In Vivo

Anti-Mouse PD-1 Antibody (RMP1-14) (10 mg/kg, ip, every 3 days for 3-4 doses) exhibits antitumor efficacy in CT26.CL25 subcutaneous tumor model with a complete response rate of 18%, but exhibits no obvious antitumor effect against CT26.CL25 liver metastatic tumor^[1].
Anti-Mouse PD-1 Antibody (RMP1-14) (50-200 μg/mouse, intradermal injection, single dose) induces acute itch in mouse models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mouse CT26.CL25 liver metastasis model^[1]
Dosage:	10 mg/kg
Administration:	ip, every 3 days for 3-4 doses
Result:	Failed to significantly change immune cells when used alone. Increased the M1/M2 ratio, increased the number of mature CD4+ T cells and CD8+ T cells, increased the expression of IFN-γ and TNF-α when used with the combination of CAPOX.

Animal Model:	C57BL/6J mouse models^[2]
Dosage:	50-200 μg/mouse
Administration:	intradermal injection, single dose
Result:	Increased the number of spontaneous scratching in mice.

Gene ID

18566 [NCBI]

Accession

Q02242

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Masse moléculaire

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse PD-1 Antibody (RMP1-14)]

Livraison

Shipping with dry ice.

Formulation

Please refer to the lot-specific COA for specific buffer information.

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Biological Activity

Immobilized PD-1 Protein, Mouse (His-Fc, HY-P73724) can bind Anti-Mouse PD-1 Antibody (RMP1-14). The EC₅₀ for this effect is 63.2 ng/mL.

Pureté et documentation

Purity: 99.63%

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Fiche technique (262 KB) SDS (251 KB)

COA (232 KB) SDS-PAGE (91 KB) SEC-HPLC (146 KB)

Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Park SJ, et al., Immune modulation of the liver metastatic colorectal cancer microenvironment via the oral CAPOX-mediated cGAS-STING pathway. Biomaterials. 2024 Oct;310:122625. [Content Brief]

[2]. Xu ZH, et al., Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse. Eur J Pharmacol. 2023 Dec 5;960:176128. [Content Brief]