Anti-Mouse Siglec-H Antibody (440c) 

Anti-Mouse Siglec-H Antibody (440c) is a rat-derived IgG2b type antibody inhibitor, targeting to mouse Siglec-H. Anti-Mouse Siglec-H Antibody (440c) recognizes sialic acid-binding immunoglobulin (Ig)-like lectin family (Siglec-H) selectively expressing on plasmacytoid DCs and interferon–producing cells. Anti-Mouse Siglec-H Antibody (440c) can be used for the researches of inflammation and immunology, such as colitis^[1][2].

Rat IgG2b

Rat IgG2b kappa, Isotype Control

Mouse

Siglec-H

Anti-Mouse Siglec-H Antibody (440c) (24 h) blocks secretion of IFN-α by murine interferon–producing cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Siglec-H Antibody (440c) (200 μg, i.p., every 24 h for 1-2 times) reduces serum levels of IFN-α and does not deplete interferon–producing cells in 129/SvJ mice^[1].
Anti-Mouse Siglec-H Antibody (440c) (200 μg, i.p., very other day) blocks the plasmacytoid DCs functional response to Toll like receptors stimulation and therapeutic effects of GM-CSF in Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis mice models^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

233274  [NCBI]

Q3Y597

in vivo administration; Flow cytometry

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse Siglec-H Antibody (440c)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Blasius A, et al. A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha. Blood. 2004 Jun 1;103(11):4201-6.  [Content Brief]

  [2]. Sainathan SK, et al. Granulocyte macrophage colony-stimulating factor ameliorates DSS-induced experimental colitis. Inflamm Bowel Dis. 2008 Jan;14(1):88-99.  [Content Brief]