Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)

Cat. No.: HY-P990818 Purity: ≥95.0%: Data Sheet
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Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) is an anti-rat FcRn heavy chain heterodimers IgG1 monoclonal antibody. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can effectively bind to FcRn and competitively inhibit the binding of IgG to FcRn. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can reduce the total serum IgG level. Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) can be used for researches on autoimmune conditions such as experimental autoimmune myasthenia gravis (EAMG). The recommend isotype control of Anti-Rat FcRn heavy chain heterodimers Antibody (1G3): Mouse IgG1 kappa, Isotype Control (HY-P99977).

For research use only. We do not sell to patients.

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) Chemical Structure

Size	Stock	Quantity
Free Sample (100 μg)	Apply Now
Free Sample (100 μg)	Apply Now
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
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100 mg	Get quote

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Description

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Rat

IC₅₀ & Target

FcRn heavy chain heterodimers

In Vivo

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) (1-30 mg/kg, i.p., at 2 and 24 h before disease induction with AChR mAb 35) almost completely prevents disease symptoms in female Lewis rats with an experimental autoimmune myasthenia gravis (EAMG) model^[1].
Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) (30 mg/kg, i.p., 3 times a week) significantly alleviate disease symptoms in female Lewis rats with an experimental autoimmune myasthenia gravis (EAMG) model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AChR mAb 35 (0.75-1 mg/kg) induced female Lewis rats (100 g)^[1]
Dosage:	1, 3, 10 and 30 mg/kg
Administration:	Intraperitoneal injection (i.p.), at 2 and 24 h before disease induction with AChR mAb 35
Result:	Significantly reduced disease score at 30 mg/kg. Significantly reduced serum mAb 35 level. Maintained normal weight and grip strength, while the control group decreased.

Animal Model:	AChR and CFA (HY-153808) induced female Lewis rats (6-7 weeks, 150 g)^[1]
Dosage:	30 mg/kg
Administration:	Intraperitoneal injection (i.p.), 3 times a week
Result:	Significantly reduced disease score. Reduced serum total IgG and anti-AChR IgG levels, but did not affect IgM. Had no effect on spleen and lymph node weight.

Application

Immunofluorescence; ELISA; Flow cytometry

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)]

Formulation

Please refer to the lot-specific COA for specific buffer information.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (260 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Liu L, et al. Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade. J Immunol. 2007 Apr 15;178(8):5390-8. [Content Brief]

[2]. Kenniston JA, et al. Structural basis for pH-insensitive inhibition of immunoglobulin G recycling by an anti-neonatal Fc receptor antibody. J Biol Chem. 2017 Oct 20;292(42):17449-17460. [Content Brief]

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Rat FcRn heavy chain heterodimers Antibody (1G3)Fc Receptor (FcR)Fc ReceptorFcRnIgGEAMGInhibitorinhibitorinhibit

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