CDK16 Antibody (YA515)

製品番号: HY-P80612: データシート SDS COA User Guide for Antibodies
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CDK16 Antibody (YA515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK16.

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容量	価格（税別）	在庫状況	数量
無料サンプル		今すぐ申し込む
10 μL	$84	在庫あり	Estimated Time of Arrival: December 31
50 μL	$222	在庫あり	Estimated Time of Arrival: December 31
100 μL	$360	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

CDK16 Antibody (YA515) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CDK16.

Host

Rabbit

Clonality

Recombinant, Monoclonal

分子量

Predicted band size: 56 kDa;

Observed band size: 65-70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

Q00536

Gene ID

5127 [NCBI]

Immunogen

Synthetic peptide corresponding to Human PCTAIRE1.The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	純度	affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol and 0.05% BSA. Preservative: 0.01% Sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro)

Subcellular Localization：Cytoplasm; Cytoplasmic vesicle, secretory vesicle; Cell membrane; Peripheral membrane protein; Cytoplasmic side; Synapse, synaptosome

Expression：
Tissue_specificity:Detected in pancreas islets (at protein level) . Detected in brain and pancreas

Isoforms & Post-Translational Modification：Q00536 has 3 isomers: Q00536-1: 55716 Da (predicted); Q00536-2: 63458 Da (predicted); Q00536-3: 56375 Da (predicted).
Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity (PubMed:22798068). Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity (By similarity). Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity (By similarity). Phosphorylation at Ser-153 inhibits kinase activity (PubMed:22798068)

Subunit：Found in a complex containing CABLES1, CDK17 and TDRD7. Interacts with BRSK2. Identified in a complex with NSF, syntaxin-1, synaptotagmin, SYN1, SYP and CDK5R1 (By similarity). Interacts with YWHAH, YWHAQ and YWHAZ. Interacts with CCNY; this interaction increases the CDK16 kinase activity (By similarity). Interacts with CCNYL1; this interaction mutually increases the stability of CDK16 and CCNYL1 and increases the kinase activity of CDK16 (By similarity). Interacts with NSF (By similarity)

RRID

AB_3102142

Database

Entrez Gene: 5127 Human

SwissProt: Q00536 Human

OMIM: 311550 Human

Research Field

Signal Transduction

Synonyms

PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE

ドキュメンテーション

Select Batch:

データシート (232 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/cho-cell.html [Content Brief]