FYB Antibody (YA973)

製品番号: HY-P81276: データシート User Guide for Antibodies
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FYB Antibody (YA973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FYB.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

FYB Antibody (YA973) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FYB.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 85 kDa;

Observed band size: 120 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O15117

Gene ID

2533 [NCBI]

Immunogen

Purified recombinant human FYB protein fragments expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (By similarity). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (PubMed:10747096, PubMed:16980616). Modulates the expression of IL2 (By similarity). Involved in platelet activation (By similarity). Prevents the degradation of SKAP1 and SKAP2 (PubMed:15849195). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (By similarity)

Subcellular Localization：Cytoplasm; Nucleus; Cell junction

Expression：
Tissue_specificity:It is expressed in hematopoietic tissues (such as myeloid cells and T cells) , spleen, and thymus. It is not expressed in B cells and non-lymphoid tissues.

Isoforms & Post-Translational Modification：O15117 has 3 isomers: O15117-1: 85387 Da (predicted); O15117-2: 90606 Da (predicted); O15117-3: 91651 Da (predicted).
T-cell receptor ligation leads to increased tyrosine phosphorylation

Subunit：Part of a complex consisting of SKAP2, FYB1, LILRB3 and PTPNS1 (By similarity).

Database

Entrez Gene: 2533 Human

SwissProt: O15117 Human

OMIM: 273900 Human

Research Field

Signal Transduction

Synonyms

ADAP; Fyb; FYN binding protein; p120/p130; SLAP130

ドキュメンテーション

User Guide for Antibodies (1077 KB)