Lysophospholipase 1 Antibody (YA2197)

Cat. No.: HY-P82452: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Lysophospholipase 1 Antibody (YA2197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lysophospholipase 1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Lysophospholipase 1 Antibody (YA2197) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Lysophospholipase 1 Antibody (YA2197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lysophospholipase 1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 25 kDa;

Observed band size: 25 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

O75608

Gene ID

10434 [NCBI]

Immunogen

A synthesized peptide derived from human Lysophospholipase 1 aa50-100/230.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:50-1:100

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Acts as an acyl-protein thioesterase (PubMed:19439193, PubMed:20418879). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (PubMed:20418879). Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1 (PubMed:22399288, PubMed:27481942, PubMed:37802024). Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes (PubMed:37802024). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (PubMed:19439193). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (By similarity). Has much higher thioesterase activity than lysophospholipase activity (PubMed:19439193). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (PubMed:21393252)

Subcellular Localization：Cytoplasm; Cell membrane; Nucleus membrane; Endoplasmic reticulum

Expression：
Tissue_specificity:Platelets

Isoforms & Post-Translational Modification：O75608 has 2 isomers: O75608-1: 24670 Da (predicted); O75608-2: 22875 Da (predicted).

Subunit：Homodimer

Database

Entrez Gene: 10434 Human ; 18777 Mouse ; 25514 Rat

SwissProt: O75608 Human ; P97823 Mouse ; P70470 Rat

OMIM: 605599 Human

Research Field

Signal Transduction

Synonyms

APT1; hAPT1; LPL1; LYPLA1; Lysophospholipase 1; LYSOPLA; LysoPLA I

Documentation

Select Batch:

Data Sheet (234 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Lysophospholipase 1 Antibody (YA2197) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Lysophospholipase 1 Antibody (YA2197)

Lysophospholipase 1 Antibody (YA2197) Featured Recommendations:

Product Detail

Background

Documentation

Lysophospholipase 1 Antibody (YA2197) Related Classifications

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