LYPLA1 - lysophospholipase 1 Gene

Also Known as APT1; LPL1; APT-1; LPL-I; hAPT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10434

About LYPLA1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:54,046,367-54,101,947 (from NCBI)

This gene has 15 transcripts (splice variants), 230 orthologues and 2 paralogues. Ubiquitous expression in urinary bladder (RPKM 38.7), testis (RPKM 35.4) and 25 other tissues.

Summary

This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

LYPLA1 Products (6)

mRNA Protein Name
NM_001279356.2 NP_001266285.1 acyl-protein thioesterase 1 isoform 2
NM_001279357.2 NP_001266286.1 acyl-protein thioesterase 1 isoform 3
NM_001279358.2 NP_001266287.1 acyl-protein thioesterase 1 isoform 4
NM_001279359.2 NP_001266288.1 acyl-protein thioesterase 1 isoform 5
NM_001279360.2 NP_001266289.1 acyl-protein thioesterase 1 isoform 6
NM_006330.4 NP_006321.1 acyl-protein thioesterase 1 isoform 1

LYPLA1 Protein Structure

Abhydrolase_2

Abhydrolase_2: Phospholipase/Carboxylesterase (11 - 225)

  • 0
  • 100
  • 200
  • 230 a.a.
Protein Preferred Names Protein Names

acyl-protein thioesterase 1

  • lysoPLA I

LYPLA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LYPLA1 O75608 SFMBT2 Homo sapiens Q5VUG0
Y2H Prey Pooling
32296183
Intra
LYPLA1 O75608 SFMBT2 Homo sapiens Q5VUG0
Validated Y2H
32296183
Intra
LYPLA1 O75608 SFMBT2 Homo sapiens Q5VUG0
Y2H Array
32296183
Intra
LYPLA1 O75608 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
LYPLA1 O75608 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
LYPLA1 O75608 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYPLA1 Proteins

Cat. No. Product Name Accession Purity
HY-P7539 APT-1/LYPLA1 Protein, Human (His) O75608 (M1-D230) ≥ 95%, as determined by reducing SDS-PAGE.

LYPLA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810677 Lysophospholipase 1 Antibody (YA9935) WB, ICC/IF, IHC-P Human, Mouse, Rat
HY-P82452 Lysophospholipase 1 Antibody (YA2197) WB, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Neuronal Ceroid Lipofuscinosis

  • Hereditary Ceroid Lipofuscinosis

  • Batten Disease

  • Ncl

  • Neuronal Ceroid-Lipofuscinoses

  • Lipofuscinosis, Ceroid, Neuronal

  • Juvenile Neuronal Ceroid Lipofuscinosis

  • Cerebromacular Dystrophy

  • Cerebromacular Degeneration

  • Ceroid-Lipofuscinosis

  • Ncl - [Neuronal Ceroid Lipofuscinosis]

  • Amaurotic Familial Idiocy

  • Amaurotic Idiocy

  • Amaurotic Idiot

  • Neuronal Lipofuscinosis

  • Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100736 ML348 Inhibitor 99.97% Unkown
HY-128035 ML-211 Inhibitor 99.42% Unkown
HY-129121 ML-​226 Inhibitor 98.76% Unkown
HY-120126 ML378 Inhibitor / Unkown
HY-RS07921 LYPLA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17852 Lypla1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24321 Lypla1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LYPLA1 VGNC VGNC:84014
Mus musculus LYPLA1 MGD MGI:1344588
Canis familiaris LYPLA1 VGNC VGNC:42890
Rattus norvegicus LYPLA1 RGD RGD:3025
Felis catus LYPLA1 VGNC VGNC:97489
Others LYPLA1 NCBI