ML-226
Based on 1 Customer Validation
ML226 is a potent inhibitor of α/β hydrolase domain protein 11 (ABHD11), with in vitro and in situ IC50 values of 15 and 0.68 nM, respectively. ML226 is an inhibitor of protein palmitoylthioesterase lysophospholipase 1 (LYPLA1) and LYPLA2. ML226 can be used for research related to neurological diseases.
For research use only. We do not sell to patients.
- Purity: 98.76%
- CAS No.: 2055172-43-3
- Formula: C23H26N4O2
- Molecular Weight:390.48
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Covalent Screening Library
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Anti-Cancer Metabolism Compound Library
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Covalent Screening Library Plus
HY-L036P
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Bioactive Compound Library
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Biological Activity
ML-226 exhibits 100 times greater selectivity for ABHD11 than approximately 20 other serine hydrolases, and can be covalently modified by carbamylation of serine residues at the active site of ABHD11[1].
ML-226 can be used as a reverse probe for ML-211 (HY-128035)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2055172-43-3
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Appearance Solid
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Molecular Weight 390.48
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Formula C23H26N4O2
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Color White to off-white
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SMILES
O=C(N1C(CC)CCCC1)N2N=CC(C(C3=CC=CC=C3)(O)C4=CC=CC=C4)=N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (256.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hsu KL, et al. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6). 2012 Apr 12 [updated 2013 Mar 14]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010–. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5610 mL | 12.8048 mL | 25.6095 mL | 64.0238 mL |
| 5 mM | 0.5122 mL | 2.5610 mL | 5.1219 mL | 12.8048 mL | |
| 10 mM | 0.2561 mL | 1.2805 mL | 2.5610 mL | 6.4024 mL | |
| 15 mM | 0.1707 mL | 0.8537 mL | 1.7073 mL | 4.2683 mL | |
| 20 mM | 0.1280 mL | 0.6402 mL | 1.2805 mL | 3.2012 mL | |
| 25 mM | 0.1024 mL | 0.5122 mL | 1.0244 mL | 2.5610 mL | |
| 30 mM | 0.0854 mL | 0.4268 mL | 0.8537 mL | 2.1341 mL | |
| 40 mM | 0.0640 mL | 0.3201 mL | 0.6402 mL | 1.6006 mL | |
| 50 mM | 0.0512 mL | 0.2561 mL | 0.5122 mL | 1.2805 mL | |
| 60 mM | 0.0427 mL | 0.2134 mL | 0.4268 mL | 1.0671 mL | |
| 80 mM | 0.0320 mL | 0.1601 mL | 0.3201 mL | 0.8003 mL | |
| 100 mM | 0.0256 mL | 0.1280 mL | 0.2561 mL | 0.6402 mL |
ML-226 Related Classifications
HY-129121 Related Classifications
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