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Cat. No.: HY-120126

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ML378

(Synonyms: CID71710938; JJH-254)

ML378 (CID71710938) is a dual LYPLA1 and LYPLA2 inhibitor, with IC₅₀s of 122 nM and 245 nM respectively. ML378 also shows potent inhibition of ABHD6 (IC₅₀ = 3.15 nM). ML378 can be used for elucidating the patho/physiological roles of the LYPLA1 and LYPLA2.

For research use only. We do not sell to patients.

CAS No.: 1831135-21-7
Formula: C₂₅H₃₂ClN₅O₆
Molecular Weight:534.00

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

ML378 Chemical Structure

CAS No.: 1831135-21-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Phospholipase Isoforms :

Chemical Information

CAS No. 1831135-21-7
Molecular Weight 534.00
Formula C₂₅H₃₂ClN₅O₆
SMILES

O=C(N1CCC(CCC2=CC=C(Cl)C=C2)CC1)ON(C3=O)C(N4C3CN(C(N5CCOCC5)=O)CC4)=O
Synonyms

CID71710938; JJH-254
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hulce JJ, et al. An in Vivo Active Carbamate-based Dual Inhibitor of Lysophospholipase 1 (LYPLA1) and Lysophospholipase 2 (LYPLA2) 2013 Dec 9 [Updated 2014 Sep 18]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
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Chemical Information
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References

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ML378

All Phospholipase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

ML378 Related Classifications

HY-120126 Related Classifications