Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)

製品番号: HY-P82915: データシート User Guide for Antibodies
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Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177).

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容量	価格（税別）	在庫状況	数量
20 μL	$164	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$249	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$405	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

顧客検証

•Bone. 2025 Jul 7:117579. [Abstract]

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177).

Host

Rabbit

Clonality

Recombinant, Monoclonal

分子量

Predicted band size: 116 kDa;

Observed band size: 105,116,138 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q7L7X3 / Q9H2K8 / Q9UL54

Gene ID

51347 [NCBI] / 57551 [NCBI] / 9344 [NCBI]

Immunogen

A synthetic phosphopeptide corresponding to residues surrounding Ser181 of human TAOK1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Phosphorylated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Q7L7X3: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. br/>Q9H2K8: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031).
Q9UL54: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway.

Subcellular Localization：Q7L7X3: Cytoplasm
Q9H2K8: Cytoplasm; Cell membrane; Peripheral membrane protein; Membrane raft; Lipid droplet
Q9UL54: Cytoplasmic vesicle membrane; Multi-pass membrane protein; Cytoplasm, cytoskeleton; Nucleus; Cell projection, dendrite

Expression：
Tissue_specificity: Q7L7X3: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle
Q9H2K8: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs) , thymus, spleen, kidney, skeletal muscle, heart and liver
Q9UL54: Ubiquitously expressed, with a higher level of expression in testis and brain
Induction: Q7L7X3: In response to DNA damage

Subunit：Q7L7X3: Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 (By similarity).
Q9H2K8: Self-associates (PubMed:13679851). Interacts with ERN1 and TRAF2 (PubMed:11278723). Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation (PubMed:11278723). Interacts (via N-terminus) with STK25; the interaction promotes STK25 abundance at the level of protein expression and/or stability (PubMed:34634521)
Q9UL54: Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the C-terminal domain. Interacts with MAP3K7 and interferes with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity)

Database

Entrez Gene: 51347 Human ; 57551 Human ; 9344 Human

SwissProt: Q7L7X3 Human ; Q9H2K8 Human ; Q9UL54 Human

OMIM: 610266 Human

Research Field

Synonyms

DPK; JIK; hKFC-A; MAP3K18

ドキュメンテーション

User Guide for Antibodies (1077 KB)