TAOK1 - TAO kinase 1 Gene

Also Known as DDIB; PSK2; TAO1; KFC-B; MARKK; PSK-2; hKFC-B; hTAOK1; MAP3K16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 57551

About TAOK1

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:29,390,363-29,551,903 (from NCBI)

This gene has 6 transcripts (splice variants), 278 orthologues, 35 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 14.1), thyroid (RPKM 11.3) and 25 other tissues.

Summary

Enables alpha-tubulin binding activity; beta-tubulin binding activity; and kinase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; negative regulation of microtubule depolymerization; and positive regulation of JNK cascade. Located in microtubule Cytoskeleton and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

TAOK1 Products (2)

mRNA	Protein	Name
NM_020791.4	NP_065842.1	serine/threonine-protein kinase TAO1 isoform 1
NM_025142.1	NP_079418.1	serine/threonine-protein kinase TAO1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	12639963	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	12639963	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	12639963	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11733138	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	17396146	GOA
involved in central nervous system neuron development	IMP IMP: Inferred from mutant phenotype	33565190	GOA
involved in execution phase of apoptosis	IDA IDA: Inferred from direct assay	16407310	GOA
involved in microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	12639963	GOA
involved in mitotic G2 DNA damage checkpoint signaling	IMP IMP: Inferred from mutant phenotype	17396146	GOA
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	12639963	GOA
involved in neuron cellular homeostasis	IMP IMP: Inferred from mutant phenotype	17900936	GOA
involved in phosphorylation	IDA IDA: Inferred from direct assay	12639963	GOA
involved in positive regulation of JNK cascade	IDA IDA: Inferred from direct assay	16407310	GOA
involved in positive regulation of protein acetylation	IMP IMP: Inferred from mutant phenotype	12639963	GOA
involved in positive regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	17396146	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in microtubule cytoskeleton	IMP IMP: Inferred from mutant phenotype	12639963	GOA
located in perinuclear region of cytoplasm	IMP IMP: Inferred from mutant phenotype	12639963	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAOK1 Protein Structure

Pkinase

0
200
400
600
800
1001 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase TAO1	MARK Kinase

TAOK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82915	Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)	WB, IHC-P	Human, Mouse, Rat
HY-P82915A	Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)(PBS only)	WB, IHC-P	Human, Mouse, Rat
HY-P83514	TAOK1 Antibody (YA3259)	WB, IP	Human, Mouse, Rat
HY-P83514A	TAOK1 Antibody (YA3259)(PBS only)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Developmental Delay With Or Without Intellectual Impairment Or Behavioral Abnormalities	DDIB
Autosomal Dominant Non-Syndromic Intellectual Disability
Macroglossia	Congenital Macroglossia Enlarged Tongue Giant Tongue Acquired Macroglossia Nos Congenital Hypertrophy Of Tongue
Fanconi Anemia, Complementation Group C	Fanconi Anemia Complementation Group C FANCC Facc Fac Fa3 Fanconi Pancytopenia Type 3 Fanconi Pancytopenia, Type 3 Faces Syndrome Facial Features , Anorexia, Cachexia, Eye And Skin Anomalies Friedman-Goodman Syndrome Abnormality Of The Face
Syndromic X-Linked Intellectual Disability Lubs Type	Lubs X-Linked Mental Retardation Syndrome Mecp2 Duplication Syndrome Mental Retardation, X-Linked, Syndromic, Lubs Type Mental Retardation, X-Linked, With Recurrent Respiratory Infections Mrxsl X-Linked Intellectual Disability-Hypotonia-Recurrent Infections Syndrome Mental Retardation, X-Linked Syndromic, Lubs Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112136	TAO Kinase inhibitor 1		99.81%	Unkown
HY-181280	VU6083859	Inhibitor	/	Unkown
HY-181281	VU6080195	Activator	/	Unkown
HY-RS14198	TAOK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-181619	TAO Kinase-IN-3	Inhibitor	/	Unkown
HY-RS18551	Taok1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25033	Taok1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TAOK1	VGNC	VGNC:97653
Macaca mulatta	TAOK1	VGNC	VGNC:81591
Bos taurus	TAOK1	VGNC	VGNC:35595
Mus musculus	TAOK1	MGD	MGI:1914490
Rattus norvegicus	TAOK1	RGD	RGD:708455
Canis familiaris	TAOK1	VGNC	VGNC:47102
Others	TAOK1	NCBI