2. Metabolic Enzyme/Protease
  3. Ser/Thr Protease
  4. VU6083859

VU6083859 is a blood-brain barrier-permeable TAOK1 inhibitor with an IC50 of 158 nM. VU6083859 selectively inhibits TAOK1, exhibits only weak or no activity against TAOK2 and TAOK3, and shows high selectivity for a variety of other kinases. VU6083859 is applicable to research related to neurodevelopmental disorders and tauopathies.

For research use only. We do not sell to patients.

VU6083859

VU6083859 Chemical Structure

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VU6083859 Related Antibodies

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Description

VU6083859 is a blood-brain barrier-permeable TAOK1 inhibitor with an IC50 of 158 nM. VU6083859 selectively inhibits TAOK1, exhibits only weak or no activity against TAOK2 and TAOK3, and shows high selectivity for a variety of other kinases. VU6083859 is applicable to research related to neurodevelopmental disorders and tauopathies.

In Vivo

VU6083859 shows central nervous system penetration with a Kp of 0.15, a half-life of 0.94 h, and a plasma clearance of 53.7 mL/min/kg in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

467.48

Formula

C26H24F3N3O2
SMILES

O=C(CCNC(C1=CC=C(C2=CC=NC(C(F)(F)F)=C2)C=C1)=O)N[C@@H](CCC3)C4=C3C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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VU6083859 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU6083859VU 6083859VU-6083859Ser/Thr ProteaseSerine proteasesSerine endopeptidasesThreonine proteasesTAOK2TAOK3central nervous systemTAOK1rathuman hepatocytestauopathiesneurodevelopmental disordersblood-brain barrierrat hepatocytesInhibitorinhibitorinhibit

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