TAO Kinase-IN-3
TAO Kinase-IN-3 is a potent pan-TAOK (Thousand-And-One Kinase) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with Kd values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 can be used to study Alzheimer's disease, primary tauopathies and related syndromes. In addition, TAO Kinase-IN-3 is also widely used in research on the mechanisms of cancer cachexia and the muscle atrophy it induces.
For research use only. We do not sell to patients.
- CAS No.: 3114565-22-6
- Formula: C24H20ClN5O2
- Molecular Weight:445.90
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All MAP3K Isoforms
More
Biological Activity
TAO Kinase-IN-3 (compound 2) binds to TAOK1, TAOK2, and TAOK3 in human HEK293 cells, with corresponding Kd values of <0.17 nM, 0.34 nM, and <0.17 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 3114565-22-6
-
Molecular Weight 445.90
-
Formula C24H20ClN5O2
-
SMILES
O=C(NC1=C(N[C@@H]2C(C=CC=C3)=C3C[C@H]2O)N=CC=C1)C4=CC=C(N5N=CC(Cl)=C5)C=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TAO Kinase-IN-3 Related Classifications
HY-181619 Related Classifications
Powered by Bioz