TAO Kinase-IN-3
Based on 1 Customer Validation
TAO Kinase-IN-3 is a potent pan-TAOK (Thousand-And-One Kinase) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with Kd values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 can be used to study Alzheimer's disease, primary tauopathies and related syndromes. In addition, TAO Kinase-IN-3 is also widely used in research on the mechanisms of cancer cachexia and the muscle atrophy it induces.
For research use only. We do not sell to patients.
- Purity: 99.21%
- CAS No.: 3114565-22-6
- Formula: C24H20ClN5O2
- Molecular Weight:445.90
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
TAO Kinase-IN-3 (compound 2) binds to TAOK1, TAOK2, and TAOK3 in human HEK293 cells, with corresponding Kd values of <0.17 nM, 0.34 nM, and <0.17 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3114565-22-6
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Appearance Solid
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Molecular Weight 445.90
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Formula C24H20ClN5O2
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SMILES
O=C(NC1=C(N[C@@H]2C(C=CC=C3)=C3C[C@H]2O)N=CC=C1)C4=CC=C(N5N=CC(Cl)=C5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (224.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2427 mL | 11.2133 mL | 22.4266 mL | 56.0664 mL |
| 5 mM | 0.4485 mL | 2.2427 mL | 4.4853 mL | 11.2133 mL | |
| 10 mM | 0.2243 mL | 1.1213 mL | 2.2427 mL | 5.6066 mL | |
| 15 mM | 0.1495 mL | 0.7476 mL | 1.4951 mL | 3.7378 mL | |
| 20 mM | 0.1121 mL | 0.5607 mL | 1.1213 mL | 2.8033 mL | |
| 25 mM | 0.0897 mL | 0.4485 mL | 0.8971 mL | 2.2427 mL | |
| 30 mM | 0.0748 mL | 0.3738 mL | 0.7476 mL | 1.8689 mL | |
| 40 mM | 0.0561 mL | 0.2803 mL | 0.5607 mL | 1.4017 mL | |
| 50 mM | 0.0449 mL | 0.2243 mL | 0.4485 mL | 1.1213 mL | |
| 60 mM | 0.0374 mL | 0.1869 mL | 0.3738 mL | 0.9344 mL | |
| 80 mM | 0.0280 mL | 0.1402 mL | 0.2803 mL | 0.7008 mL | |
| 100 mM | 0.0224 mL | 0.1121 mL | 0.2243 mL | 0.5607 mL |
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