3114565-22-6
Chemical Structure
TAO Kinase-IN-3
- CAS No.: 3114565-22-6
- Formula:C24H20ClN5O2
- Molecular Weight:445.90
InChIKey: LHRASHSNGREPST-FGZHOGPDSA-N
SMILES: O=C(NC1=C(N[C@@H]2C(C=CC=C3)=C3C[C@H]2O)N=CC=C1)C4=CC=C(N5N=CC(Cl)=C5)C=C4
Biological Activity: TAO Kinase-IN-3 is a potent pan-TAOK (Thousand-And-One Kinase) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with Kd values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 can be used to study Alzheimer's disease, primary tauopathies and related syndromes. In addition, TAO Kinase-IN-3 is also widely used in research on the mechanisms of cancer cachexia and the muscle atrophy it induces[1].
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TAO Kinase-IN-3 | TAO Kinase-IN-3 is a potent pan-TAOK (Thousand-And-One Kinase) inhibitor that specifically binds to and inhibits the kinase activities of TAOK1, TAOK2 and TAOK3 with Kd values of <0.17 nM, 0.34 nM, and 0.17 nM, respectively. TAO Kinase-IN-3 can be used to study Alzheimer's disease, primary tauopathies and related syndromes. In addition, TAO Kinase-IN-3 is also widely used in research on the mechanisms of cancer cachexia and the muscle atrophy it induces. | |||||||||||||||||||||
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Keywords
