TAOK3 - TAO kinase 3 Gene

Also Known as DPK; JIK; hKFC-A; MAP3K18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51347

About TAOK3

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:118,149,801-118,372,907 (from NCBI)

This gene has 19 transcripts (splice variants), 299 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 12.0), prostate (RPKM 9.7) and 25 other tissues.

Summary

The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]

TAOK3 Products (12)

mRNA Protein Name
NM_001346487.2 NP_001333416.1 serine/threonine-protein kinase TAO3 isoform a
NM_001346488.2 NP_001333417.1 serine/threonine-protein kinase TAO3 isoform b
NM_001346489.2 NP_001333418.1 serine/threonine-protein kinase TAO3 isoform b
NM_001346490.2 NP_001333419.1 serine/threonine-protein kinase TAO3 isoform c
NM_001346491.2 NP_001333420.1 serine/threonine-protein kinase TAO3 isoform d
NM_001346492.2 NP_001333421.1 serine/threonine-protein kinase TAO3 isoform d
NM_001346493.2 NP_001333422.1 serine/threonine-protein kinase TAO3 isoform e
NM_001346494.2 NP_001333423.1 serine/threonine-protein kinase TAO3 isoform f
NM_001346495.2 NP_001333424.1 serine/threonine-protein kinase TAO3 isoform f
NM_001346496.2 NP_001333425.1 serine/threonine-protein kinase TAO3 isoform g
NM_001346497.2 NP_001333426.1 serine/threonine-protein kinase TAO3 isoform g
NM_016281.4 NP_057365.3 serine/threonine-protein kinase TAO3 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11278723 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
10559204 GOA
enables transferase activity IDA
IDA: Inferred from direct assay
10559204 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
17396146 GOA
involved in MAPK cascade IMP
IMP: Inferred from mutant phenotype
10924369 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17396146 GOA
involved in negative regulation of JNK cascade IDA
IDA: Inferred from direct assay
10559204 GOA
involved in positive regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
10924369 GOA
involved in positive regulation of JUN kinase activity IMP
IMP: Inferred from mutant phenotype
11278723 GOA
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: Inferred from mutant phenotype
17396146 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
10559204 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
10559204 GOA
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
11278723 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAOK3 Protein Structure

Pkinase

Pkinase: Protein kinase domain (28 - 277)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase TAO3

  • CTCL-associated antigen HD-CL-09

TAOK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TAOK3 Q9H2K8 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
11278723
Intra
TAOK3 Q9H2K8 TRAF2 Homo sapiens Q12933
Anti Tag CoIP
11278723
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TAOK3 Proteins

Cat. No. Product Name Accession Purity
HY-P77222 TAOK3 Protein, Human (Active, sf9, His) Q9H2K8 (M1-D411) ≥ 95%, as determined by reducing SDS-PAGE.

TAOK3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82915 Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660) WB, IHC-P Human, Mouse, Rat
HY-P82915A Phospho-TAOK1/2/3 (Ser181/Ser181/Ser177) Antibody (YA2660)(PBS only) WB, IHC-P Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181280 VU6083859 Inhibitor / Unkown
HY-181281 VU6080195 Activator / Unkown
HY-RS14200 TAOK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181619 TAO Kinase-IN-3 Inhibitor / Unkown
HY-RS19748 Taok3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26245 Taok3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TAOK3 VGNC VGNC:35597
Canis familiaris TAOK3 VGNC VGNC:47104
Macaca mulatta TAOK3 VGNC VGNC:81593
Felis catus TAOK3 VGNC VGNC:80496
Mus musculus TAOK3 MGD MGI:3041177
Rattus norvegicus TAOK3 RGD RGD:1562861
Others TAOK3 NCBI