TXNIP Antibody (YA1627)
(Synonyms: HHCPA78; THIF; TXNIP; VDUP1; Thioredoxin Interacting Protein Antibody)TXNIP Antibody (YA1627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TXNIP.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB, IHC-P, ICC/IF, FC
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 | 1:50-1:200 | 1:50-1:100 |
Product Details
TXNIP Antibody (YA1627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TXNIP.
-
Host Rabbit
-
Clonality Recombinant, Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 44 kDa
Entrez Gene: 10628 Human ; 56338 Mouse ; 117514 Rat
SwissProt: Q9H3M7 Human ; Q8BG60 Mouse ; Q5M7W1 Rat
OMIM: 606599 Human
A synthesized peptide derived from human TXNIP
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Liquid
-
Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
TXNIP may act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1)[1][2][3][4].
-
Subcellular Localization
Cytoplasm; Nucleus
-
Expression
Induction:By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress -
Isoforms & Post-Translational Modification
Q9H3M7 has 2 isomers: Q9H3M7-1: 43661 Da (predicted); Q9H3M7-2: 37319 Da (predicted).
Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation (PubMed:29378950). Deubiquitinated by USP5, leading to TXNIP stabilization (PubMed:37534934) -
Subunit
Homodimer; disulfide-linked (PubMed:23519408). Interacts with TXN/thioredoxin through its redox-active site (PubMed:17603038). Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (PubMed:12821938). Interacts with DDIT4 (PubMed:21460850)
-
SwissProt ID
-
Synonyms
HHCPA78; THIF; TXNIP; VDUP1; Thioredoxin Interacting Protein Antibody
-
Research Field
Signal Transduction
Documentation
Powered by Bioz
