TXNIP Antibody (YA1627)

製品番号: HY-P81882: データシート User Guide for Antibodies
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TXNIP Antibody (YA1627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TXNIP.

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容量	価格（税別）	在庫状況	数量
20 μL	$146	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	$222	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	$360	Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

Synthetic products have potential research and development risk.

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明
参考文献

製品説明

TXNIP Antibody (YA1627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TXNIP.

Host

Rabbit

Clonality

Recombinant, Monoclonal

分子量

Predicted band size: 44 kDa;

Observed band size: 53 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9H3M7

Gene ID

10628 [NCBI]

Immunogen

A synthesized peptide derived from human TXNIP

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
FC FC: Flow Cytometry	1:50-1:100

Sensitivity	Endogenous	純度	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850)

Subcellular Localization：Cytoplasm; Nucleus

Expression：
Induction:By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress

Isoforms & Post-Translational Modification：Q9H3M7 has 2 isomers: Q9H3M7-1: 43661 Da (predicted); Q9H3M7-2: 37319 Da (predicted).
Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation (PubMed:29378950). Deubiquitinated by USP5, leading to TXNIP stabilization (PubMed:37534934)

Subunit：Homodimer; disulfide-linked (PubMed:23519408). Interacts with TXN/thioredoxin through its redox-active site (PubMed:17603038). Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (PubMed:12821938). Interacts with DDIT4 (PubMed:21460850)

Database

Entrez Gene: 10628 Human ; 56338 Mouse ; 117514 Rat

SwissProt: Q9H3M7 Human ; Q8BG60 Mouse ; Q5M7W1 Rat

OMIM: 606599 Human

Research Field

Signal Transduction

Synonyms

HHCPA78; THIF; TXNIP; VDUP1; Thioredoxin Interacting Protein Antibody

ドキュメンテーション

User Guide for Antibodies (1077 KB)

参考文献

[1]. /biology-dictionary/a549-cell.html [Content Brief]