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  5. TXNIP Antibody (YA1627)

TXNIP Antibody (YA1627)

Cat. No.: HY-P81882
User Guide for Antibodies Technical Support

TXNIP Antibody (YA1627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TXNIP.

For research use only. We do not sell to patients.

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20 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
50 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
100 μL Get quote 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

TXNIP Antibody (YA1627) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TXNIP.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 44 kDa;
Observed band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human TXNIP
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
FC
FC: Flow Cytometry
1:50-1:100
Sensitivity Endogenous Purity Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850)
Subcellular Localization：Cytoplasm; Nucleus
Expression：
Induction:By 1,25-dihydroxyvitamin D-3 and TGFB1. Down-regulated in response to oxidative stress
Isoforms & Post-Translational Modification：Q9H3M7 has 2 isomers: Q9H3M7-1: 43661 Da (predicted); Q9H3M7-2: 37319 Da (predicted).
Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation (PubMed:29378950). Deubiquitinated by USP5, leading to TXNIP stabilization (PubMed:37534934)
Subunit：Homodimer; disulfide-linked (PubMed:23519408). Interacts with TXN/thioredoxin through its redox-active site (PubMed:17603038). Interacts with transcriptional repressors ZBTB16, ZBTB32 and HDAC1 (PubMed:12821938). Interacts with DDIT4 (PubMed:21460850)
Database

Entrez Gene: 10628 Human ; 56338 Mouse ; 117514 Rat

SwissProt: Q9H3M7 Human ; Q8BG60 Mouse ; Q5M7W1 Rat

OMIM: 606599 Human

Research Field

Signal Transduction
Synonyms
HHCPA78; THIF; TXNIP; VDUP1; Thioredoxin Interacting Protein Antibody
Documentation
User Guide for Antibodies (1077 KB)

TXNIP Antibody (YA1627) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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TXNIP Antibody (YA1627)
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