TXNIP - thioredoxin interacting protein Gene

Also Known as THIF; VDUP1; ARRDC6; HHCPA78; EST01027

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10628

About TXNIP

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,992,435-145,996,579 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 1044.5), spleen (RPKM 514.7) and 23 other tissues.

Summary

This gene encodes a thioredoxin-binding protein that is a member of the alpha Arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of Reactive Oxygen Species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

TXNIP Products (2)

mRNA Protein Name
NM_001313972.2 NP_001300901.1 thioredoxin-interacting protein isoform 2
NM_006472.6 NP_006463.3 thioredoxin-interacting protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
17603038 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10814541 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
20068034 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to tumor cell IDA
IDA: Inferred from direct assay
18541147 GOA
involved in keratinocyte differentiation IDA
IDA: Inferred from direct assay
14632196 GOA
involved in negative regulation of cell division IDA
IDA: Inferred from direct assay
18541147 GOA
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
17603038 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
14632196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TXNIP Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (10 - 152)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (175 - 298)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

thioredoxin-interacting protein

  • thioredoxin binding protein 2

TXNIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TXNIP Q9H3M7 ECD Homo sapiens O95905
Anti Tag CoIP
38270169
Intra
TXNIP Q9H3M7 VAV2 Homo sapiens P52735
ITC
26919541
Intra
TXNIP Q9H3M7 VAV2 Homo sapiens P52735
X-Ray Diffraction
26919541
Intra
TXNIP Q9H3M7 HDAC2 Homo sapiens Q92769
Anti Bait CoIP
38270169
Intra
TXNIP Q9H3M7 HDAC2 Homo sapiens Q92769
Anti Tag CoIP
38270169
Intra
TXNIP Q9H3M7 TXN Homo sapiens P10599
Y2H
10814541
Intra
TXNIP Q9H3M7 TXN Homo sapiens P10599
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

TXNIP Antibodies

Cat. No. Product Name Application Reactivity
HY-P80361 TXNIP Antibody (YA024) WB, ICC/IF, IHC-P, FC Human, Mouse, Rat
HY-P81882 TXNIP Antibody (YA1627) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P81882A TXNIP Antibody (YA1627)(PBS only) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Leukostasis
Hyperglycemia
Hyperlipidemia, Familial Combined, 3

  • Familial Combined Hyperlipidemia

  • Combined Hyperlipidemia, Familial

  • Mixed Hyperlipidaemia

  • FCHL3

  • Hyperlipidemia, Familial Combined

  • Familial Multiple Lipoprotein-Type Hyperlipidemia

  • Hyperbetalipoproteinemia With Prebetalipoproteinemia

  • Type Iib Hyperlipoproteinemia

  • Hyperlipidemia Familial Combined

  • Hyperlipoproteinemia Type Iib

  • Mixed Hyperlipemia

  • Hyperlipidaemia, Group C

  • Familial Hypercholesterolaemia With Hyperlipaemia

  • Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

  • Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

  • Hypercholesterolaemia With Endogenous Hyperglyceridaemia

  • Prebetalipoproteinemia Hyperbetalipoproteinaemia

  • Remnant Hyperlipoproteinemia
Exocervical Carcinoma

  • Carcinoma Of Exocervix

  • Carcinoma Of The Exocervix
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diabetes Mellitus

  • Diabetes
Heart Disease

  • Heart Failure

  • Congenital Heart Disease

  • Heart Diseases

  • Congenital Heart Defects

  • Congenital Heart Defect

  • Heart Malformation

  • Congenital Anomaly Of Heart

  • Heart Defect

  • Heart-Congenital Defect

  • Congenital Heart Disorder

  • Heart Defects Congenital

  • Heart Defects, Congenital

  • Heart Defects

  • Heart Disease, Congenital

  • Disease, Heart, Congenital

  • Congestive Heart Failure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0004 Doxofylline 99.97% Yes

Pre-clinical Phase

Bioactive Molecules (18)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-19330 DASA-58 Activator 99.57% Unkown
HY-141623 SRI-37330 hydrochloride Inhibitor 99.72% Unkown
HY-142114 SRI-37330 Inhibitor 99.16% Unkown
HY-113328 Aminoadipic acid 99.94% Unkown
HY-N0496 Ruscogenin Inhibitor 99.85% Unkown
HY-122682 SBI-993 98.79% Unkown
HY-115688 TXNIP-IN-1 Inhibitor 99.19% Unkown
HY-124418 SBI-477 Inhibitor 98.0% Unkown
HY-155248 HL23 99.64% Unkown
HY-115688A (S)-TXNIP-IN-1 Control 99.73% Unkown
HY-RS16561 Txnip Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15295 TXNIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-Z15823 (R)-Verapamil 98.97% Unkown
HY-123996 3-Ethoxy-5,6-dibromosalicylaldehyde / Unkown
HY-149216 Anticancer agent 103 / Unkown
HY-169298 Ferroptosis-IN-15 Inhibitor / Unkown
HY-181335 SKL1223 Inhibitor / Unkown
HY-RS22993 Txnip Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TXNIP VGNC VGNC:79059
Canis familiaris TXNIP VGNC VGNC:48017
Felis catus TXNIP VGNC VGNC:66730
Bos taurus TXNIP VGNC VGNC:36541
Rattus norvegicus TXNIP RGD RGD:620886
Mus musculus TXNIP MGD MGI:1889549
Others TXNIP NCBI