2. Gene
  3. TXNIP - thioredoxin interacting protein Gene

TXNIP - thioredoxin interacting protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as THIF; VDUP1; ARRDC6; HHCPA78; EST01027

Gene ID: 10628 | Gene type: protein coding

About TXNIP

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,992,435-145,996,579 (from NCBI)

This gene has 4 transcripts (splice variants), 288 orthologues and 5 paralogues. Ubiquitous expression in fat (RPKM 1044.5), spleen (RPKM 514.7) and 23 other tissues.

Summary

This gene encodes a thioredoxin-binding protein that is a member of the alpha Arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of Reactive Oxygen Species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

TXNIP Products(2)

mRNA Protein Name
NM_001313972.2 NP_001300901.1 thioredoxin-interacting protein isoform 2
NM_006472.6 NP_006463.3 thioredoxin-interacting protein isoform 1

TXNIP Protein Structure

Arrestin_N

Arrestin_N: Arrestin (or S-antigen), N-terminal domain (10 - 152)

Arrestin_C

Arrestin_C: Arrestin (or S-antigen), C-terminal domain (175 - 298)

  • 0
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  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

thioredoxin-interacting protein

thioredoxin binding protein 2

Related Diseases

Diseases Alias
Leukostasis
Hyperglycemia
Hyperlipidemia, Familial Combined, 3

Familial Combined Hyperlipidemia

Combined Hyperlipidemia, Familial

Mixed Hyperlipidaemia

FCHL3

Hyperlipidemia, Familial Combined

Familial Multiple Lipoprotein-Type Hyperlipidemia

Hyperbetalipoproteinemia With Prebetalipoproteinemia

Type Iib Hyperlipoproteinemia

Hyperlipidemia Familial Combined

Hyperlipoproteinemia Type Iib

Mixed Hyperlipemia

Hyperlipidaemia, Group C

Familial Hypercholesterolaemia With Hyperlipaemia

Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia

Hyperbetalipoproteinaemia With Prebetalipoproteinaemia

Hypercholesterolaemia With Endogenous Hyperglyceridaemia

Prebetalipoproteinemia Hyperbetalipoproteinaemia

Remnant Hyperlipoproteinemia
Exocervical Carcinoma

Carcinoma Of Exocervix

Carcinoma Of The Exocervix
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diabetes Mellitus

Diabetes
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0004 Doxofylline 99.65% Yes
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-19330 DASA-58 Activator 99.73% Unkown
HY-142114 SRI-37330 Inhibitor 98.76% Unkown
HY-141623 SRI-37330 hydrochloride Inhibitor 99.05% Unkown
HY-115688 TXNIP-IN-1 99.15% Unkown
HY-N0496 Ruscogenin Inhibitor 99.59% Unkown
HY-124418 SBI-477 Inhibitor ≥98.0% Unkown
HY-122682 SBI-993 98.67% Unkown
HY-115688A (S)-TXNIP-IN-1 99.73% Unkown
HY-RS15295 TXNIP Human Pre-designed siRNA Set A / Unkown
HY-149216 Anticancer agent 103 / Unkown
HY-155248 HL23 / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TXNIP VGNC VGNC:79059
Canis familiaris TXNIP VGNC VGNC:48017
Felis catus TXNIP VGNC VGNC:66730
Bos taurus TXNIP VGNC VGNC:36541
Rattus norvegicus TXNIP RGD RGD:620886
Mus musculus TXNIP MGD MGI:1889549