1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Adenosine Receptor
    Phosphodiesterase (PDE)
  3. Doxofylline

Doxofylline 

Cat. No.: HY-B0004 Purity: 99.32%
Handling Instructions

Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

For research use only. We do not sell to patients.

Doxofylline Chemical Structure

Doxofylline Chemical Structure

CAS No. : 69975-86-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Doxofylline is an antagonist of adenosine A1 receptor which also inhibits phosphodiesterase IV.

IC50 & Target

Adenosine A1 receptor, phosphodiesterase IV[1]

Clinical Trial
Molecular Weight

266.25

Formula

C₁₁H₁₄N₄O₄

CAS No.

69975-86-6

SMILES

O=C(N1C)N(C)C2=C(N(CC3OCCO3)C=N2)C1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (187.79 mM; Need ultrasonic)

H2O : 25 mg/mL (93.90 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7559 mL 18.7793 mL 37.5587 mL
5 mM 0.7512 mL 3.7559 mL 7.5117 mL
10 mM 0.3756 mL 1.8779 mL 3.7559 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.39 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DoxofyllineAdenosine ReceptorPhosphodiesterase (PDE)P1 receptorInhibitorinhibitorinhibit

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Product Name:
Doxofylline
Cat. No.:
HY-B0004
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