2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein Apoptosis
  3. Calcium Channel Potassium Channel Somatostatin Receptor Arrestin Apoptosis P-glycoprotein
  4. (R)-Verapamil

(R)-Verapamil  (Synonyms: Dexverapamil)

Cat. No.: HY-Z15823 Purity: 98.97%
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(R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp).

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(R)-Verapamil

(R)-Verapamil Chemical Structure

CAS No. : 38321-02-7

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Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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(R)-Verapamil Related Antibodies

Top Publications Citing Use of Products

View All Calcium Channel Isoform Specific Products:

View All Isoforms
N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

View All Somatostatin Receptor Isoform Specific Products:

View All Isoforms
SSTR1 SSTR2 SSTR3 SSTR5 SSTR4

View All Arrestin Isoform Specific Products:

View All Isoforms
Arrestin-2/β-Arrestin 1 Arrestin-3/β-Arrestin 2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(R)-Verapamil (Dexverapamil) is an optically enantiomer of the oral-active Verapamil (HY-14275). (R)-Verapamil has a relatively low affinity for L-type calcium channels (Cav1.2) (IC50 > 300 μM), and its IC50 for sodium channels (sodium channel) is 3.19 μM. (R)-Verapamil exhibits SSTR2 agonistic activity, with an EC50 of 1.3 μM. (R)-Verapamil significantly downregulates the expression of TXNIP protein in diabetic mouse models and significantly inhibits β-cell apoptosis (apoptosis), effectively controlling blood sugar. (R)-Verapamil can be used as a PET tracer for the function of P-glycoprotein (P-gp)[1][2][3].

Cellular Effect
Cell Line Type Value Description References
MES-SA/Dx5 IC50
5.52 μM
Compound: Verapamil (R)
TP_TRANSPORTER: drug resistance (paclitaxel) in MES-SA/DX5 cells
TP_TRANSPORTER: drug resistance (paclitaxel) in MES-SA/DX5 cells
[PMID: 12569305]
Molecular Weight

454.60

Formula

C27H38N2O4
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

COC(C=C1CCN(C)CCC[C@](C#N)(C2=CC(OC)=C(C=C2)OC)C(C)C)=C(C=C1)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (27.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1997 mL 10.9987 mL 21.9974 mL
5 mM 0.4399 mL 2.1997 mL 4.3995 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1997 mL 10.9987 mL 21.9974 mL 54.9934 mL
5 mM 0.4399 mL 2.1997 mL 4.3995 mL 10.9987 mL
10 mM 0.2200 mL 1.0999 mL 2.1997 mL 5.4993 mL
15 mM 0.1466 mL 0.7332 mL 1.4665 mL 3.6662 mL
20 mM 0.1100 mL 0.5499 mL 1.0999 mL 2.7497 mL
25 mM 0.0880 mL 0.4399 mL 0.8799 mL 2.1997 mL
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(R)-Verapamil Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-Verapamil38321-02-7DexverapamilCalcium ChannelPotassium ChannelSomatostatin ReceptorArrestinApoptosisP-glycoproteinCa2+ channelsCa channelsKcsASSTRsSSTRP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243PET imagingcardiovascular effectsenantiomersdiabetes mellitusTXNIPpharmacokineticsInhibitorinhibitorinhibit

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