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SBI-477 

Cat. No.: HY-124418 Purity: >98.0%
Handling Instructions

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes.

For research use only. We do not sell to patients.

SBI-477 Chemical Structure

SBI-477 Chemical Structure

CAS No. : 781628-99-7

Size Price Stock Quantity
1 mg USD 315 In-stock
Estimated Time of Arrival: December 31
5 mg USD 950 In-stock
Estimated Time of Arrival: December 31
10mM/1ml USD 1050 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

SBI-477 is a chemical probe stimulated insulin signaling by deactivating the transcription factor MondoA, leading to reduced expression of the insulin pathway suppressors thioredoxin-interacting protein (TXNIP) and arrestin domain–containing 4 (ARRDC4). SBI-477 coordinately inhibits triacylglyceride (TAG) synthesis and enhances basal glucose uptake in human skeletal myocytes[1].

IC50 & Target

MondoA[1]

Molecular Weight

483.54

Formula

C₂₄H₂₅N₃O₆S

CAS No.

781628-99-7

SMILES

O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)C3=CC=C(OCC(N4CCOCC4)=O)C(OC)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 65 mg/mL (134.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0681 mL 10.3404 mL 20.6808 mL
5 mM 0.4136 mL 2.0681 mL 4.1362 mL
10 mM 0.2068 mL 1.0340 mL 2.0681 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (4.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (4.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SBI-477SBI477SBI 477OthersInhibitorinhibitorinhibit

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Product Name:
SBI-477
Cat. No.:
HY-124418
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