SRI-37330 hydrochloride
Based on 5 publication(s) in Google Scholar
SRI-37330 hydrochloride is an orally bioavailable thioredoxin-interacting protein (TXNIP) inhibitor. SRI-37330 hydrochloride inhibits glucagon secretion and function, reduces hepatic glucose production and reverses hepatic steatosis. SRI-37330 hydrochloride can be used for type 2 diabetes research.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 2322245-49-6
- Formula: C16H20ClF3N4O2S
- Molecular Weight:424.87
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) SRI-37330 hydrochloride
MoreAll Arrestin Isoforms
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Biological Activity
TXNIP[1]
SRI-37330 (1 μM, 24 h) hydrochloride inhibits the activity of the human TXNIP promoter in INS-1 cells[1].
SRI-37330 (1 μM, 24 h) hydrochloride inhibits Mrna and protein levels of TXNIP in INS-1 cells[1].
SRI-37330 (5 μM, 24 h) hydrochloride inhibits polymerase II (Pol II) binding to the E-box motif region of the TXNIP promoter[1].
SRI-37330 (5 μM, 24 h) hydrochloride lowers glucagon secretion in TC1-6 cells[1].
SRI-37330 (0-5 μM, 24 h) hydrochloride inhibits glucagon-induced glucose output from primary hepatocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride is well tolerated in male C57BL/6J mice[1].
SRI-37330 (100 mg/kg, p.o., in drinking water, 3 weeks) hydrochloride reverses obesity- and Streptozotocin (STZ) (HY-13753)-induced diabetes and hepatic steatosis in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2322245-49-6
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Appearance Solid
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Molecular Weight 424.87
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Formula C16H20ClF3N4O2S
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Color White to light yellow
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SMILES
O=S(NCC1CN(CCC1)C2=C3C=C(C(F)(F)F)C=CC3=NC=N2)(C)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
TXNIP upregulation controls metabolism and cell cycle during androgen deprivation therapy in prostate cancer. [Abstract]2025 Nov 10;16(1):817. PMID: 41213907 -
J Biochem Mol Toxicol
Sesamol Alleviated Lipotoxicity-Induced Dysfunction in MIN6 Cells via Facilitating Cellular Senescence Caused by Endoplasmic Reticulum Stress. [Abstract]2024 Nov;38(11):e70038. PMID: 39470143 -
Exp Eye Res
Resveratrol protects lens epithelial cells and delays cataract development via inhibiting TXNIP mediated oxidative stress and apoptosis. [Abstract]2026 Jun:267:110969. PMID: 41864488 -
Biomed Pharmacother
Mitigation of nicotine-induced podocyte injury through inhibition of thioredoxin interacting protein. [Abstract]2025 Jun:187:118110. PMID: 40311224 -
Solvent & Solubility
H2O : 100 mg/mL (235.37 mM; Need ultrasonic)
DMSO : 62.5 mg/mL (147.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 2.3537 mL | 11.7683 mL | 23.5366 mL | 58.8415 mL |
| 5 mM | 0.4707 mL | 2.3537 mL | 4.7073 mL | 11.7683 mL | |
| 10 mM | 0.2354 mL | 1.1768 mL | 2.3537 mL | 5.8842 mL | |
| 15 mM | 0.1569 mL | 0.7846 mL | 1.5691 mL | 3.9228 mL | |
| 20 mM | 0.1177 mL | 0.5884 mL | 1.1768 mL | 2.9421 mL | |
| 25 mM | 0.0941 mL | 0.4707 mL | 0.9415 mL | 2.3537 mL | |
| 30 mM | 0.0785 mL | 0.3923 mL | 0.7846 mL | 1.9614 mL | |
| 40 mM | 0.0588 mL | 0.2942 mL | 0.5884 mL | 1.4710 mL | |
| 50 mM | 0.0471 mL | 0.2354 mL | 0.4707 mL | 1.1768 mL | |
| 60 mM | 0.0392 mL | 0.1961 mL | 0.3923 mL | 0.9807 mL | |
| 80 mM | 0.0294 mL | 0.1471 mL | 0.2942 mL | 0.7355 mL | |
| 100 mM | 0.0235 mL | 0.1177 mL | 0.2354 mL | 0.5884 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SRI-37330 hydrochloride Related Classifications
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