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  2. Primary Antibodies
  3. Toll-Like Receptor 4 Antibody

Toll-Like Receptor 4 Antibody

Cat. No.: HY-P80918
COA User Guide for Antibodies

Toll-Like Receptor 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 96 kDa, targeting to Toll-Like Receptor 4. It can be used for WB,FC assays with tag free, in the background of Human.

For research use only. We do not sell to patients.

Size Price Stock Quantity
Free Sample   Apply now  
10 μL $110 In-stock
50 μL $290 In-stock
100 μL $460 In-stock
250 μL   Get quote  

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Top Publications Citing Use of Products
  • Biological Activity

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Description

Toll-Like Receptor 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 96 kDa, targeting to Toll-Like Receptor 4. It can be used for WB,FC assays with tag free, in the background of Human.

Background

Toll-Like Receptor 4: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]

Tag

Free

Gene ID

7099

Synonyms
TLR4; Toll-like receptor 4; hToll; CD antigen CD284
Molecular Weight

Predicted band size: 96 kDa

Purity

affinity purified

Conjugation

Non-conjugated

Research Field

Immunology

Product Categories

Primary Antibody; Rabbit Polyclonal Antibody

Host

Rabbit

Reactivity

Human

SwissProt ID

O00206

Dilution Ratio

WB: 1:500-1:1,000 ;FC: 1:50-1:100

Application

WB, FC

Appearance

Liquid

Formulation

Supplied in 1*PBS (pH 7.3). Preservative: 0.09% sodium azide or 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Isotype

IgG

Immunogen

Synthetic peptide corresponding to Human TLR4.AA range:669-698 or KLH conjugated synthetic peptide derived from human TLR4: 121-200/839.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Toll-Like Receptor 4 Antibody
Cat. No.:
HY-P80918
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