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AP-1/NF-κB activation inhibitor 1 

Cat. No.: HY-133987 Purity: 99.70%
Handling Instructions

AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells.

For research use only. We do not sell to patients.

AP-1/NF-κB activation inhibitor 1 Chemical Structure

AP-1/NF-κB activation inhibitor 1 Chemical Structure

CAS No. : 188936-12-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 220 In-stock
Estimated Time of Arrival: December 31
5 mg USD 200 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
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100 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
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Description

AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].

Molecular Weight

344.25

Formula

C₁₃H₁₁F₃N₄O₄

CAS No.

188936-12-1

SMILES

O=C(C1=CN=C(C(F)(F)F)N=C1NN2C(C(C)=CC2=O)=O)OCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (726.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9049 mL 14.5243 mL 29.0487 mL
5 mM 0.5810 mL 2.9049 mL 5.8097 mL
10 mM 0.2905 mL 1.4524 mL 2.9049 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

AP-1/NF-κB activation inhibitor 1NF-κBNuclear factor-κBNuclear factor-kappaBtranscriptionalactivationstimulatedIL-2IL-8Inhibitorinhibitorinhibit

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Product Name:
AP-1/NF-κB activation inhibitor 1
Cat. No.:
HY-133987
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