188936-12-1
Chemical Structure
AP-1/NF-κB activation inhibitor 1
- No. CAS: 188936-12-1
- Formula:C13H11F3N4O4
- Molecular Weight:344.25
IUPAC Name: ethyl 4-((3-methyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)amino)-2-(trifluoromethyl)pyrimidine-5-carboxylate
InChIKey: JWIIKHRJOUQCQG-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(C(F)(F)F)N=C1NN2C(C(C)=CC2=O)=O)OCC
Biological Activity: AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].
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AP-1/NF-κB activation inhibitor 1 | 98.08% | AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells. | ||||||||||||||||||||
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Keywords
