2. GPCR/G Protein
  3. Leukotriene Receptor
  4. BAY-u 9773

BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis.

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BAY-u 9773

BAY-u 9773 화학구조

CAS No. : 154978-38-8

사이즈 가격 재고 수량
Solution
25 μg (211.58 μM * 250 μL in Ethanol) 견적 받기 3 - 4 Weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks
Liquid
50 μg 견적 받기

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고객리뷰

Based on 1 publication(s) in Google Scholar

BAY-u 9773 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE BAY-u 9773

View All Leukotriene Receptor Isoform Specific Products:

View All Isoforms
LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

  • Biological Activity

  • 순도&문서

  • References

  • 고객리뷰

제품 설명

BAY-u 9773 is a selective cysteinyl-leukotriene receptor antagonist. BAY-u 9773 competitively antagonizes cysteinyl-leukotriene-induced contractions at typical and atypical cysteinyl-leukotriene receptors with comparable activity. BAY-u 9773 can be used for the research of trichomoniasis[1][2].

IC50 & Target[1]

CysLT1

 

CysLT2

 

Cellular Effect
Cell Line Type Value Description References
CHO IC50
0.44 μM
Compound: BAY-u9773
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT1 receptor expressed in CHO cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
[PMID: 25408836]
HEK293 IC50
0.3 μM
Compound: BAY-u9773
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
Antagonist activity at human CysLT2 receptor expressed in HEK293 cells assessed as inhibition of LTD4-inudced intracellular calcium influx preincubated for 30 mins before LTD4 addition by Fura2-AM assay
[PMID: 25408836]
In Vitro

BAY u9773 (10 nM-10 μM; 15 min) competitively displaces [3H] leukotriene D4 binding to guinea-pig lung membranes with a mean pKi of 7.0[1].
BAY-u 9773 (1-10 μM; 30 min pretreatment) dose-dependently inhibits TvSP- and LTC4-induced MCP-1 secretion in HMC-1 cells, with the strongest effect observed at 10 μM[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced ROS production in HMC-1 cells, with significant suppression at concentrations ≥1 μM[2].
BAY-u 9773 (5 μM) inhibits TvSP- and LTC4-induced migration of HMC-1 cells by approximately 60%[2].
BAY-u 9773 (1-5 μM) dose-dependently inhibits TvSP- and LTC4-induced degranulation (measured via CD63 expression) in HMC-1 cells, with the strongest effect at 5 μM[2].
BAY-u 9773 inhibits TvSP-induced p47phox phosphorylation in HMC-1 cells[2].
BAY-u 9773 inhibits TvSP- and LTC4-induced NF-κB phosphorylation in HMC-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY-u 9773 Related Antibodies

ELISA Assay[2]

Cell Line: HMC-1
Concentration: 1 μM; 3 μM; 10 μM
Incubation Time: 30 min pretreatment
Result: Dose-dependently inhibited TvSP-induced MCP-1 secretion, reducing levels to ~260 pg/mL at 10 μM compared to ~460 pg/mL in untreated TvSP-stimulated cells.
Dose-dependently inhibited LTC4-induced MCP-1 secretion, reducing levels to ~270 pg/mL at 10 μM compared to ~460 pg/mL in untreated LTC4-stimulated cells.
In Vivo

BAY-u 9773 (i.v.) induces dose-related bronchoconstriction in anaesthetized guinea-pigs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

472.64

화학식

C27H36O5S
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

OC(CCC[C@H](O)[C@@H](/C=C/C=C/C=C\C/C=C\CCCCC)SC1=CC=C(C=C1)C(O)=O)=O
선적

Shipping with dry ice.
보관

-80°C, protect from light
순도&문서

Purity: 95.5%

SDS (393 KB)

COA (242 KB)

Handling Instructions (2659 KB)
References
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BAY-u 9773 Related Classifications

  • 몰농도 계산기

  • 농도 희석 계산기

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-u 9773154978-38-8Leukotriene ReceptorMCP-1trichomoniasisleukotriene D4leukotriene C4HMC-1 cellscysteinyl-leukotriene receptor antagonistguinea-pig lung homogenateguinea-pigNF-κBcysteinyl-leukotriene receptorsInhibitorinhibitorinhibit

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상품명:
BAY-u 9773
Cat. No.:
HY-107609
수량:
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SAFETY DATA SHEET (SDS)

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