2. Immunology/Inflammation Apoptosis
  3. Galectin Apoptosis
  4. Belapectin

Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.

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Belapectin

Belapectin Estructura química

No. CAS : 1980787-47-0

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Belapectin Related Antibodies

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Descripciòn

Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2].

IC50 & Target

Galectin-3

 

In Vitro

Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) inhibits the proliferation of 4T1 and MCA-205 cells and induced apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Belapectin Related Antibodies

Apoptosis Analysis[1]

Cell Line: TRAMP-C1, 4T1 and MCA-205 cells
Concentration: 0.2 mg/mL, 2 mg/mL
Incubation Time: 48 h
Result: Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.
In Vivo

Belapectin (2.4 mg/mouse; i.p.; 3 times per week for 3 weeks) only exerts function under the combination with anti-OX40 mAb, does cause a significant reduction in tumor growth and a corresponding increase in survival. The combined treatment also produces lasting long-term memory, and 100 percent of the tumor-free mice were protected from subsequent tumor reattacks[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type C57BL/6 and BALB/c mice[1]
Dosage: 2.4 mg/mouse, accompanied with anti-OX40 mAb (250 µg)
Administration: Intraperitoneal injection; 3 times per week for 3 weeks
Result: Inhibited tumor growth.
Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
Ensayo clínico
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

[Belapectin]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

H2O : 10 mg/mL (ultrasonic and warming and heat to 60°C)

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Pureza y Documentación

Purity: 98.94%

SDS (251 KB)

COA (245 KB) HNMR (205 KB) RP-HPLC (2030 KB)

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Belapectin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belapectin1980787-47-0GR-MD-02GalectinApoptosisInhibitorinhibitorinhibit

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Nombre del producto:
Belapectin
Cat. No.:
HY-114440
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