2. Immunology/Inflammation Apoptosis
  3. Galectin Apoptosis
  4. Belapectin

Belapectin  (Synonyms: GR-MD-02)

製品番号: HY-114440 純度: 98.94%
COA 取扱説明書 Technical Support

Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM.

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Belapectin

Belapectin 構造式

CAS 番号 : 1980787-47-0

容量 価格（税別） 在庫状況 数量
1 mg $440 在庫あり
5 mg $1100 在庫あり
10 mg $1760 在庫あり
25 mg $3520 在庫あり
50 mg $5630 在庫あり
100 mg $9000 在庫あり
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Belapectin 関連抗体

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Galectin アイソフォーム固有の製品をすべて表示:

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Galectin-1 Galectin-3 Galectin-4 Galectin-8

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製品説明

Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity Ki of 2.8 μM[1][2].

IC50 & Target

Galectin-3

 

体外実験

Belapectin (0.2 mg/mL, 2 mg/mL; 48 h) inhibits the proliferation of 4T1 and MCA-205 cells and induced apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Belapectin 関連抗体

Apoptosis Analysis[1]

Cell Line: TRAMP-C1, 4T1 and MCA-205 cells
Concentration: 0.2 mg/mL, 2 mg/mL
Incubation Time: 48 h
Result: Decreased the proliferation and resulted a minimal increase in apoptosis of 4T1 and MCA-205 cells. But showed no impact on TRAMP-C1 cell.
体内実験

Belapectin (2.4 mg/mouse; i.p.; 3 times per week for 3 weeks) only exerts function under the combination with anti-OX40 mAb, does cause a significant reduction in tumor growth and a corresponding increase in survival. The combined treatment also produces lasting long-term memory, and 100 percent of the tumor-free mice were protected from subsequent tumor reattacks[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type C57BL/6 and BALB/c mice[1]
Dosage: 2.4 mg/mouse, accompanied with anti-OX40 mAb (250 µg)
Administration: Intraperitoneal injection; 3 times per week for 3 weeks
Result: Inhibited tumor growth.
Enhanced the efficacy of checkpoint blockade (aPD-L1) immunotherapy.
臨床実験
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

[Belapectin]
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : 10 mg/mL (ultrasonic and warming and heat to 60°C)

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純度とドキュメンテーション

純度: 98.94%

COA (245 KB) HNMR (205 KB) RP-HPLC (2030 KB)

取扱説明書 (2659 KB)
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Belapectin1980787-47-0GR-MD-02GalectinApoptosisInhibitorinhibitorinhibit

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