2. Membrane Transporter/Ion Channel
  3. NKCC
  4. Bendroflumethiazide

ベンドロフルメチアジド  (Synonyms: Bendroflumethiazide; Bendrofluazide)

製品番号: HY-B1363 純度: 99.16%
COA 取扱説明書 Technical Support

Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus.

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Bendroflumethiazide

ベンドロフルメチアジド 構造式

CAS 番号 : 73-48-3

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 在庫あり
Solution
10 mM * 1 mL in DMSO USD 66 在庫あり
Solid
50 mg $60 在庫あり
100 mg $100 在庫あり
200 mg $160 在庫あり
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1 g   お問い合わせ  

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ベンドロフルメチアジド 関連抗体

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製品説明

Bendroflumethiazide (Bendrofluazide) is an orally available diuretic. Bendroflumethiazide inhibits the electroneutral sodium-chloride symporter located in the apical membrane of the early segment of the distal convoluted tubule and can effectively lower blood pressure. Bendroflumethiazide is used in the study of hypertension and edema. Bendroflumethiazide has an antidiuretic effect in diabetes insipidus[1][2].

体内実験

Bendroflumethiazide (125 mg/kg, p.o. 12 days) reduces body weight, decreases urine flow, and increases urine osmolality in the Brattleboro rat model of diabetes insipidus, exerts an antidiuretic effect through sustained sodium loss[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Brattleboro rats with hereditary DI (female 200 g) [2]
Dosage: 125 mg/kg
Administration: p.o., 12 days
Result: Showed a weight loss of approximately 3%, but did not change average daily food intake.
Reduced urine flow, increased urine osmotic pressure, and reduced free water clearance.
臨床実験
分子量

421.41

分子式

C15H14F3N3O4S2
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=S(C1=C(C(F)(F)F)C=C(C2=C1)NC(CC3=CC=CC=C3)NS2(=O)=O)(N)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 250 mg/mL (593.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3730 mL 11.8649 mL 23.7299 mL
5 mM 0.4746 mL 2.3730 mL 4.7460 mL
10 mM 0.2373 mL 1.1865 mL 2.3730 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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一般には略語で表示されます：C1V1 = C2V2

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純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3730 mL 11.8649 mL 23.7299 mL 59.3246 mL
5 mM 0.4746 mL 2.3730 mL 4.7460 mL 11.8649 mL
10 mM 0.2373 mL 1.1865 mL 2.3730 mL 5.9325 mL
15 mM 0.1582 mL 0.7910 mL 1.5820 mL 3.9550 mL
20 mM 0.1186 mL 0.5932 mL 1.1865 mL 2.9662 mL
25 mM 0.0949 mL 0.4746 mL 0.9492 mL 2.3730 mL
30 mM 0.0791 mL 0.3955 mL 0.7910 mL 1.9775 mL
40 mM 0.0593 mL 0.2966 mL 0.5932 mL 1.4831 mL
50 mM 0.0475 mL 0.2373 mL 0.4746 mL 1.1865 mL
60 mM 0.0395 mL 0.1977 mL 0.3955 mL 0.9887 mL
80 mM 0.0297 mL 0.1483 mL 0.2966 mL 0.7416 mL
100 mM 0.0237 mL 0.1186 mL 0.2373 mL 0.5932 mL
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Bendroflumethiazide Related Classifications

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
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Keywords:

Bendroflumethiazide73-48-3BendrofluazideNKCCNa-K-Cl cotransporterNa(+)-K(+)-Cl(-) cotransporterNa+-K+-Cl− cotransporteroraldiureticantihypertensivearterial hypertensive diseaseBrattleboro ratsdiabetes insipidus,Inhibitorinhibitorinhibit

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