2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Endogenous Metabolite
  4. Betaine

ベタイン  (Synonyms: Betaine; Trimethylglycine; carboxy-N,N,N-trimethylmethanaminium)

製品番号: HY-B0710 純度: 99.97%
COA 取扱説明書 Technical Support

Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns[1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 107-43-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in Water USD 27 在庫あり
Solid
5 g $25 在庫あり
10 g $33 在庫あり
25 g $47 在庫あり
50 g $60 在庫あり
100 g $72 在庫あり
> 100 g   お問い合わせ  

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カスタマーレビュー

Based on 5 publication(s) in Google Scholar

Other Forms of Betaine:

ベタイン 関連抗体

Top Publications Citing Use of Products

    Betaine purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2025 Apr.

    Betaine (orally at a dose of 400 mg/kg, daily, two months). Western blot representative images display protein expression levels of TGF-β1, Smad2/3, p-Smad2/3, and α-SMA.

    Betaine purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2025 Apr.

    Betaine (orally at a dose of 400 mg/kg, daily, two months). Immunohistochemistry was performed on each group for assessing the expression of Caspase-3.

    Betaine purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2025 Apr.

    Results from cell viability assessments under Betaine (1 mM, one week) in CCSMCs (n = 6).

    Betaine purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2025 Apr.

    Betaine (1 mM, one week). Flow cytometry images and apoptosis rates across CCSMC groups are also depicted.

    Betaine purchased from MedChemExpress. Usage Cited in: J Funct Foods. 2025 Apr.

    Betaine (orally at a dose of 400 mg/kg, daily, two months). Examples of immunofluorescence and relative fluorescence intensities of Bcl-2 (n = 3).

    Endogenous Metabolite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Human Endogenous Metabolite Microbial Metabolite

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    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Betaine (Trimethylglycine) is a natural compound found in many foods and also an active methyl-donor which can maintain normal DNA methylation patterns[1,2]. Betaine is found ubiquitously in plants, animals, microorganisms, and rich dietary sources including seafood, spinach, and wheat bran. Betaine also acts as an osmolyte, to maintain the avian’s cellular water and ion balance to improve the avian’s capacity against heat stress via preventing dehydration and osmotic inactivation. It helps in maintaining the protective osmolytic activity, especially in heat-stressed birds. Betaine may promote various intestinal microbes against osmotic variations and thus improve microbial fermentation activity[3].

    IC50 & Target

    Microbial Metabolite

     

    Human Endogenous Metabolite

     

    体外実験

    Betaine (Trimethylglycine) inhibites proliferation of HeLa cells significantly[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    ベタイン 関連抗体
    体内実験

    Betaine (Trimethylglycine) attenuates liver-to-body weight ratio[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    臨床実験
    分子量

    117.15

    分子式

    C5H11NO2
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C[N+](C)(C)CC([O-])=O
    Structure Classification
    Initial Source

    Widespread
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
    溶剤 & 溶解度
    体外: 

    H2O : 100 mg/mL (853.61 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 8.5361 mL 42.6803 mL 85.3606 mL
    5 mM 1.7072 mL 8.5361 mL 17.0721 mL
    10 mM 0.8536 mL 4.2680 mL 8.5361 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

    =
    濃度 （終了）

    C2

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    体積 （終了）

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.97%

    COA (246 KB) HNMR (108 KB) RP-HPLC (217 KB)

    取扱説明書 (2659 KB)
    参考文献
    細胞実験
    [1]

    Cytotoxic effects of Betaine are evaluated by MTT assays. Briefly, 5×103 HeLa or MCF-10A cells/well are seeded in a 96-well plate and cultured overnight. Then, different concentrations of Betaine (from 0 to 100 mg/mL) are added to each well, and the MTT assay is performed at 24, 48, 72 and 96 h after incubation. Cu/Zn-SOD activities are detected using the superoxide dismutase Assay Kit according to the manufacturer’s instructions[1].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    動物実験
    [2]

    Male C57BL/6 mice weighing 25±0.5 g are used in this study. Animals are randomly assigned to four groups (n=6 to 8 per group) and pair-fed a modified Lieber-DeCarli alcohol (AF) or isocaloric maltose dextrin control liquid diet (PF) for 5 weeks with a stepwise feeding procedure. The ethanol content starts at 30% of total calories and gradually increases up to 36% in the last week. Betaine is administered as a supplement in the liquid diets (both PF and AF) at a concentration of 0.5% (w/v), simultaneously with the alcohol. All animals have access to diet and water ad libitum. At the end of the experiment, the mice are killed after being deprived of food for 4 h, and the plasma, liver and epididymal fat pad samples are harvested for assays[2].

    MedChemExpress (MCE) はこれらの方法の精度を確認していません。 こちらは参照専用です。
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 8.5361 mL 42.6803 mL 85.3606 mL 213.4016 mL
    5 mM 1.7072 mL 8.5361 mL 17.0721 mL 42.6803 mL
    10 mM 0.8536 mL 4.2680 mL 8.5361 mL 21.3402 mL
    15 mM 0.5691 mL 2.8454 mL 5.6907 mL 14.2268 mL
    20 mM 0.4268 mL 2.1340 mL 4.2680 mL 10.6701 mL
    25 mM 0.3414 mL 1.7072 mL 3.4144 mL 8.5361 mL
    30 mM 0.2845 mL 1.4227 mL 2.8454 mL 7.1134 mL
    40 mM 0.2134 mL 1.0670 mL 2.1340 mL 5.3350 mL
    50 mM 0.1707 mL 0.8536 mL 1.7072 mL 4.2680 mL
    60 mM 0.1423 mL 0.7113 mL 1.4227 mL 3.5567 mL
    80 mM 0.1067 mL 0.5335 mL 1.0670 mL 2.6675 mL
    100 mM 0.0854 mL 0.4268 mL 0.8536 mL 2.1340 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Betaine Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Betaine107-43-7Trimethylglycine carboxy-N,N,N-trimethylmethanaminiumEnvironmental PollutantsEndogenous MetaboliteEnvironmental ContaminantsInhibitorinhibitorinhibit

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