2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras
  4. BI-2493

BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.

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BI-2493

BI-2493 構造式

CAS 番号 : 2937344-16-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 1320 在庫あり
Solution
10 mM * 1 mL in DMSO USD 1320 在庫あり
Solid
1 mg $650 在庫あり
5 mg $1300 在庫あり
10 mg $1820 在庫あり
25 mg $2980 在庫あり
50 mg $3970 在庫あり
100 mg $5288 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

BI-2493 関連抗体

Top Publications Citing Use of Products

Ras アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
K-Ras H-Ras N-Ras Ras

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

BI-2493 is a structural analogue of BI-2865 and a highly selective and orally active pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research[1].

IC50 & Target

K-Ras WT

 

体外実験

BI-2493 (0-10 μM, 72 h) inhibits the proliferation of KRAS mutant cancer cell lines in a concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BI-2493 関連抗体

Cell Viability Assay[1]

Cell Line: ASPC1 cells (G12D), HPAC cells (G12D), H727 cells (G12V) (BaF3 cells transduced with a virus derived from plasmids expressing KRAS G12D or G12V mutants)
Concentration: 0, 100 nM, 1000 nM, 10000 nM
Incubation Time: 72 h
Result: Effectively inhibited the proliferation of cancer cells ASPC1 (G12D), HPAC (G12D), and H727 (G12V)
体内実験

BI-2493 (90 mg/kg, p.o., twice daily for 21 days) exhibits tumor-suppressive activity in LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LS513/GP2d/HPAC/SW620/MIAPACA2-derived xenograft NMRI mice models
Dosage: 90 mg/kg
Administration: Oral gavage (p.o.), twice daily for 21 days
Result: Reduced tumor growth in mice carrying KRAS G12C, G12D, G12V, and A146V mutation models, without causing significant toxicity to the mice.
分子量

461.58

分子式

C24H27N7OS
CAS 番号
Appearance

Solid

Color

Off-white to yellow

SMILES

N#CC1=C(N)SC2=C1[C@]3(CCC2)C4=C(CCC3)C(C5=NC(N6[C@H](CNCC6)C)=NC=C5)=NO4
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (108.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1665 mL 10.8324 mL 21.6647 mL
5 mM 0.4333 mL 2.1665 mL 4.3329 mL
10 mM 0.2166 mL 1.0832 mL 2.1665 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

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体積 （開始）

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.79%

COA (253 KB) HNMR (139 KB) LCMS (93 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1665 mL 10.8324 mL 21.6647 mL 54.1618 mL
5 mM 0.4333 mL 2.1665 mL 4.3329 mL 10.8324 mL
10 mM 0.2166 mL 1.0832 mL 2.1665 mL 5.4162 mL
15 mM 0.1444 mL 0.7222 mL 1.4443 mL 3.6108 mL
20 mM 0.1083 mL 0.5416 mL 1.0832 mL 2.7081 mL
25 mM 0.0867 mL 0.4333 mL 0.8666 mL 2.1665 mL
30 mM 0.0722 mL 0.3611 mL 0.7222 mL 1.8054 mL
40 mM 0.0542 mL 0.2708 mL 0.5416 mL 1.3540 mL
50 mM 0.0433 mL 0.2166 mL 0.4333 mL 1.0832 mL
60 mM 0.0361 mL 0.1805 mL 0.3611 mL 0.9027 mL
80 mM 0.0271 mL 0.1354 mL 0.2708 mL 0.6770 mL
100 mM 0.0217 mL 0.1083 mL 0.2166 mL 0.5416 mL
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BI-2493 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BI-24932937344-16-4BI2493BI 2493RasASPC1 cells (G12D)HPAC cells (G12D)H727 cells (G12V)Anti-cancer activityInhibitorinhibitorinhibit

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