2. Anti-infection
  3. RSV
  4. BMS-433771

BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease.

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BMS-433771

BMS-433771 構造式

CAS 番号 : 543700-68-1

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 682 在庫あり
Solution
10 mM * 1 mL in DMSO USD 682 在庫あり
Solid
5 mg $620 在庫あり
10 mg $770 在庫あり
25 mg $1100 在庫あり
50 mg $1750 在庫あり
100 mg $2800 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of BMS-433771:

BMS-433771 関連抗体

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製品説明

BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2].

IC50 & Target

EC50: 20 nM (RSV)[1]
Cellular Effect
Cell Line Type Value Description References
A549 IC50
13 nM
Compound: 1
Antiviral activity against Respiratory syncytial virus A2 infected in A549 cells after 3 days by CelltitreGlo assay
Antiviral activity against Respiratory syncytial virus A2 infected in A549 cells after 3 days by CelltitreGlo assay
[PMID: 23265891]
HEp-2 CC50
> 100 μM
Compound: 3; BMS433771
Cytotoxicity against human Hep2 cells after 4 days
Cytotoxicity against human Hep2 cells after 4 days
[PMID: 28772235]
HEp-2 CC50
> 100 μM
Compound: 5, BMS-433771
Cytotoxicity against human Hep2 cells assessed as cell viability after 6 days by CCK-8 assay
Cytotoxicity against human Hep2 cells assessed as cell viability after 6 days by CCK-8 assay
[PMID: 25941547]
HEp-2 CC50
> 100 μM
Compound: BMS-433771
Cytotoxicity against human Hep2 cells after 5 days by CCK8 assay
Cytotoxicity against human Hep2 cells after 5 days by CCK8 assay
[PMID: 29456794]
HEp-2 CC50
> 211 μM
Compound: 7h
Cytotoxicity against HEp2 cells
Cytotoxicity against HEp2 cells
[PMID: 17169560]
HEp-2 CC50
> 218 μM
Compound: 6m, BMS-433771
Cytotoxicity against HEp2 cells
Cytotoxicity against HEp2 cells
[PMID: 17169560]
HEp-2 EC50
0.028 μM
Compound: 5, BMS-433771
Antiviral activity against Respiratory syncytial virus A infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 6 days by CCK-8 assay
Antiviral activity against Respiratory syncytial virus A infected in human Hep2 cells assessed as reduction of virus-induced cytopathic effect after 6 days by CCK-8 assay
[PMID: 25941547]
HeLa CC50
> 100 μM
Compound: 4; BMS-433771
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 3 days by ATPlite assay
Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 3 days by ATPlite assay
[PMID: 32407115]
体外実験

BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM[1].
BMS-433771 can inhibit viral F protein-induced membrane fusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-433771 関連抗体
体内実験

BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing, but has considerable pharmacodynamic differences between the two rodent models[2]
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: rodent models of RSV infection[2]
(cotton rat and mice)
Dosage: 1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat)
Administration: oral, single or bid 4 days
Result: Had prophylactic efficacy via oral dosing in both animal models.
Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.
分子量

377.44

分子式

C21H23N5O2
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1=C2C=CN=C1)CC3=NC4=CC=CC=C4N3CCCCO)N2C5CC5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 6.25 mg/mL (16.56 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 2.5 mg/mL (6.62 mM; ultrasonic and adjust pH to 4 with HCl)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6494 mL 13.2471 mL 26.4943 mL
5 mM 0.5299 mL 2.6494 mL 5.2989 mL
10 mM 0.2649 mL 1.3247 mL 2.6494 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 99.84%

COA (253 KB) HNMR (128 KB) LCMS (102 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6494 mL 13.2471 mL 26.4943 mL 66.2357 mL
5 mM 0.5299 mL 2.6494 mL 5.2989 mL 13.2471 mL
DMSO 10 mM 0.2649 mL 1.3247 mL 2.6494 mL 6.6236 mL
15 mM 0.1766 mL 0.8831 mL 1.7663 mL 4.4157 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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BMS-433771 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-433771543700-68-1BMS433771BMS 433771RSVRespiratory syncytial virusrespiratory syncytial virus (RSV)oralrespiratory tract diseaseviral Fmembrane fusionInhibitorinhibitorinhibit

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製品名:
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製品番号:
HY-120632
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