BMS-433771 dihydrochloride hydrate
Based on 1 Customer Validation
BMS-433771 dihydrochloride hydrate is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 dihydrochloride hydrate is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 dihydrochloride hydrate can be used for the research of respiratory tract disease.
For research use only. We do not sell to patients.
- Purity: 98.00%
- CAS No.: 543700-67-0
- Formula: C21H27Cl2N5O3
- Molecular Weight:468.38
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 20 nM (RSV)[1]
BMS-433771 dihydrochloride hydrate has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM[1].
BMS-433771 dihydrochloride hydrate can inhibit viral F protein-induced membrane fusion[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 543700-67-0
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Appearance Solid
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Molecular Weight 468.38
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Formula C21H27Cl2N5O3
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Color Off-white to light yellow
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SMILES
O=C(N1C2CC2)N(CC3=NC4=CC=CC=C4N3CCCCO)C5=C1C=CN=C5.[H]Cl.[H]Cl.[H]O[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (106.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Christopher Cianci, et al. Antiviral activity and molecular mechanism of an orally active respiratory syncytial virus fusion inhibitor. J Antimicrob Chemother [Content Brief]
[2]. Christopher Cianci, et al. Oral efficacy of a respiratory syncytial virus inhibitor in rodent models of infection. Antimicrob Agents Chemother. 2004 Jul;48(7):2448-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1350 mL | 10.6751 mL | 21.3502 mL | 53.3755 mL |
| 5 mM | 0.4270 mL | 2.1350 mL | 4.2700 mL | 10.6751 mL | |
| 10 mM | 0.2135 mL | 1.0675 mL | 2.1350 mL | 5.3375 mL | |
| 15 mM | 0.1423 mL | 0.7117 mL | 1.4233 mL | 3.5584 mL | |
| 20 mM | 0.1068 mL | 0.5338 mL | 1.0675 mL | 2.6688 mL | |
| 25 mM | 0.0854 mL | 0.4270 mL | 0.8540 mL | 2.1350 mL | |
| 30 mM | 0.0712 mL | 0.3558 mL | 0.7117 mL | 1.7792 mL | |
| 40 mM | 0.0534 mL | 0.2669 mL | 0.5338 mL | 1.3344 mL | |
| 50 mM | 0.0427 mL | 0.2135 mL | 0.4270 mL | 1.0675 mL | |
| 60 mM | 0.0356 mL | 0.1779 mL | 0.3558 mL | 0.8896 mL | |
| 80 mM | 0.0267 mL | 0.1334 mL | 0.2669 mL | 0.6672 mL | |
| 100 mM | 0.0214 mL | 0.1068 mL | 0.2135 mL | 0.5338 mL |
BMS-433771 dihydrochloride hydrate Related Classifications
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