1. Anti-infection
  2. RSV


Cat. No.: HY-12983 Purity: 99.15%
Handling Instructions

ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.

For research use only. We do not sell to patients.
ALS-8112 Chemical Structure

ALS-8112 Chemical Structure

CAS No. : 1445379-92-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 581 In-stock
1 mg USD 180 In-stock
5 mg USD 420 In-stock
10 mg USD 600 In-stock
50 mg USD 1800 In-stock
100 mg USD 2520 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Other Forms of ALS-8112:

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


ALS-8112 is a potent and selective respiratory syncytial virus (RSV) polymerase inhibitor. The 5'-triphosphate of ALS-8112 inhibits RSV polymerase with an IC50 of 0.02 μM.

IC50 & Target

IC50: 0.02 μM (RSV)[1]

In Vitro

The 5'-triphosphate form of ALS-8112 (ALS-8112-TP) is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis[2]. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate with a half-life of approximately 29 hours. The nucleoside triphosphate analogue inhibits RSV replication by means of chain termination[3]. ALS-8112 is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV–RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM[4].

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.4051 mL 17.0253 mL 34.0507 mL
5 mM 0.6810 mL 3.4051 mL 6.8101 mL
10 mM 0.3405 mL 1.7025 mL 3.4051 mL
Please refer to the solubility information to select the appropriate solvent.
Cell Assay

ALS-8112 and its prodrug ALS-8176 are stored at 4°C in dimethyl sulfoxide (DMSO), and diluted in water. HEp-2 cells per well are plated in a 96-well plate. Each compound is serially diluted (1:3) up to 9 distinct concentrations. Cells are pre-incubated with compounds for 24 hours at 37°C in a 5% CO2 atmosphere. After 24 hours of pre-incubation with compounds, RSV A2, Long, or B1 at a multiplicity of infection (MOI) of 0.5 is added to the cells, except for the background controls. The plate is then incubated for additional 4 days in the same conditions and at the end of the incubation 50 μL the supernatant from each well of the plate is collected[4]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







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Pure form -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 47 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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