Bosakitug  (Synonyms: BSI-045B; TQC2731)

Bosakitug (BSI-045B) is an TSLP-targeting IgG1κ type humanized antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Bosakitug can be used in the research of inflammatory diseases such as moderate to severe atopic dermatitis^[1].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

TSLP

TSLP is a key regulator of type 2 (Th2) immune responses at the barrier surfaces of the skin, respiratory tract, and gastrointestinal tract. The expression level of TSLP is significantly elevated in models of atopic diseases such as atopic dermatitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

85480  [NCBI]

Q969D9-1

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

145.507 kDa

2762183-23-1

Liquid

Colorless to light yellow

[Bosakitug]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  IgG1-kappa

• 
  Loaded Bosakitug on AHC2 biosensor, can bind TSLP Protein, Human (HEK293, His, HY-P70818) with an affinity constant of 4.639E-10 M as determined in BLI assay.

• [1]. Parish J L, et al. 717-Clinical efficacy, safety, and pharmacokinetic profile of bosakitug (BSI-045B), an anti-thymic stromal lymphopoietin (TSLP) mAb in a phase 2 study of moderate and severe atopic dermatitis subjects. British Journal of Dermatology, 2024, 191(Supplement_2): ljae266. 090.