2. Autophagy
  3. Autophagy
  4. CA77.1

CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research.

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CAS. Nr. : 2412270-22-3

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Based on 7 publication(s) in Google Scholar

CA77.1 Related Antibodies

Top Publications Citing Use of Products

    CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597.

    CA77.1 (20 μM; 24-48 h) decreased the expression of FN and α-SMA, and increased LAMP2A in TGF-β-treated NIH3T3 cells.

    CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597.

    CA77.1 (20 μM; 24-48 h) decreased the expression of FN and α-SMA, and increased LAMP2A in TGF-β-treated LX-2 cells.

    CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597.

    CA77.1 (10 mg/kg; i.p.; once daily for 2 weeks) improved respiratory function, as reflected by increased tidal volume and minute ventilation in pulmonary fibrosis mice.

    CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597.

    CA77.1 (10 mg/kg; i.p.; once daily for 2 weeks) reduced fibrotic pathology in pulmonary fibrosis mice.

    CA77.1 purchased from MedChemExpress. Usage Cited in: Sci Transl Med. 2026 Feb 18;18(837):eads9597.

    CA77.1 (10 mg/kg; i.p.; once daily for 2 weeks) reduced FN, LAMP2A, and α-SMA expression in lung tissue of pulmonary fibrosis mice.

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    Beschreibung

    CA77.1 is a potent, brain-penetrant and orally active chaperone-mediated autophagy (CMA) activator with favorable pharmacokinetics. CA77.1 is a derivative of AR7 (HY-101106) and can increase the expression of the lysosomal receptor LAMP2A in?lysosomes. CA77.1 improves behavior and neuropathology in PS19 mice model and can be used for alzheimer's?disease research[1].

    In Vitro

    CA77.1 (0-30 μM; 16 hours) activates CMA in a dose-and time-dependent manner to NIH 3T3 cells stably expressing the KFERQ-PS-Dendra reporter. The CMA activity is quantified as the average of fluorescent puncta per cell[1].
    CA77.1 (20 μM; 6 hours) does not alter on LC3-II expression, and does not effects autophagic flux in NIH 3T3 cells[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    CA77.1 Related Antibodies
    In Vivo

    CA77.1 (oral gavage; 10 mg/kg;single dose) demonstrates brain penetrance with favorable pharmacokinetics. The Cmax, AUClast, Tmax and T1/2 are 3534 ng/g, 8338 h*ng/g, 1 hour and 1.89 hour, respectively[1].
    CA77.1 (oral gavage; 30 mg/kg; 6 months) normalizes the previously described locomotor hyperactivity of PS19 mice to control levels. And it reduces the levels and number of neurons containing pathogenic tau conformations in the hippocampus, amygdala, and piriform cortex. And the higher number of microglial cells and presence of large Iba1-positive cells with rod-like dystrophic morphology in vehicle-treated PS19 mice are reduced upon CA77.1 treatment[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 9-month-old CTR or PS19 mice[1]
    Dosage: 30 mg/kg
    Administration: Oral gavage; 30 mg/kg; 6 months
    Result: Improved behavior and neuropathology in a mouse model of frontotemporal-dementia-related proteotoxicity.
    Molekulargewicht

    297.74

    Formel

    C16H12ClN3O
    CAS. Nr.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    CC(NC1=CC=C(C2=NC3=CC=C(Cl)C=C3N=C2)C=C1)=O
    Versand

    Room temperature in continental US; may vary elsewhere.
    Speicherung

    4°C, protect from light

    *In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

    Lösungsmittel & Löslichkeit
    In Vitro: 

    DMSO : 5 mg/mL (16.79 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Ethanol : < 1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.3586 mL 16.7932 mL 33.5864 mL
    5 mM 0.6717 mL 3.3586 mL 6.7173 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

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    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 3.3586 mL 16.7932 mL 33.5864 mL 83.9659 mL
    5 mM 0.6717 mL 3.3586 mL 6.7173 mL 16.7932 mL
    10 mM 0.3359 mL 1.6793 mL 3.3586 mL 8.3966 mL
    15 mM 0.2239 mL 1.1195 mL 2.2391 mL 5.5977 mL
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    CA77.1 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    CA77.12412270-22-3AutophagyCMAalzheimer's diseaseADLAMP2AneuropathologyderivativeKFERQInhibitorinhibitorinhibit

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