Chlorin e6 trisodium  (Synonyms: Ce6 trisodium)

Chlorin e6 Ce6 (trisodium) is a water-soluble derivative of chlorophyll, belonging to the chlorin class of photosensitizers with an absorption wavelength range of 600-670 nm. Chlorin e6 trisodium emits characteristic red fluorescence upon light excitation, enabling real-time identification of tumor boundaries and progression. Chlorin e6 trisodium can be used for the study of photodynamic therapy (PDT) of cancers (bladder cancer) and fluorescence diagnosis of neoplastic lesions^[1][2][3].

Chlorin e6 trisodium (24 h incubation followed by irradiation) shows dark cytotoxicity in HeLa cells with an IC₅₀ of 13 μM and phototoxicity with an IC₅₀ of 0.83 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chlorin e6 trisodium (2.5-5 mg/kg, i.v., single dose) shows high phototoxicity and induces significantly higher tumor necrosis combined with laser irradiation in MGH xenograft-bearing Balb/c nude mice^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

662.62

C₃₄H₃₃N₄Na₃O₆

72984-36-2

Solid

Brown to black

O=C(O[Na])C/C1=C2[C@H]([C@@H](C(/C=C3N/C(C(C=C)=C\3C)=C\C4=N/C(C(CC)=C4C)=C\C5=C(C)C(C(O[Na])=O)=C1N5)=N\2)C)CCC(O[Na])=O

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Chin WW, et al. The potential application of chlorin e6-polyvinylpyrrolidone formulation in photodynamic therapy. Photochem Photobiol Sci. 2006 Nov;5(11):1031-7.  [Content Brief]

  [2]. Chin WW, et al. Fluorescence imaging and phototoxicity effects of new formulation of chlorin e6-polyvinylpyrrolidone. J Photochem Photobiol B. 2006 Aug 1;84(2):103-10.  [Content Brief]

  [3]. Rybkin AY, et al. Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity. Pharmaceutics. 2023 Jan 12;15(1):273.  [Content Brief]