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  4. Coppersensor 1

Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu+ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu+) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases.

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CAS 番号 : 874748-20-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 388 在庫あり
Solution
10 mM * 1 mL in DMSO USD 388 在庫あり
Solid
1 mg $110 在庫あり
5 mg $280 在庫あり
10 mg $420 在庫あり
50 mg   お問い合わせ  
100 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 29 publication(s) in Google Scholar

Other Forms of Coppersensor 1:

Coppersensor 1 関連抗体

Top Publications Citing Use of Products

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 13:e02501.  [Abstract]

    Analysis of monovalent copper ion levels in TRIM21‐knockdown KYSE30 cells following 0.5 mm CuSO4 treatment (CS1, 5 μM, 10 min).

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Jul 13:e02501.  [Abstract]

    Analysis of monovalent copper ion levels in TRIM21‐knockdown KYSE450 cells following 0.5 mm CuSO4 treatment (CS1, 5 μM, 10 min).

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Stem Cell Res Ther. 2025 Sep 29;16(1):526.  [Abstract]

    Copper sensor probe (Red) (5 μM; 30 min) was used.

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Int J Mol Med. 2025 Oct;56(4):154.  [Abstract]

    Copper sensor 1 (5 μM; 30 min). Fluorescence staining indicated that intracellular copper ion levels were elevated in U87 and U251 cells following SDF2 knockdown compared with those in control cells (n = 3, scale bar, 50 µm).

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 13;15(1):6947.  [Abstract]

    RNA-qPCR fold-changes of select transcripts 4 h post-supplementation of 500 nM CuGTSM or 5 µM CS1 relative to DMSO treated A549 cells.

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Mater Today Bio. 2024 May 11:26:101087.

    Representative fluorescent images of intracellular Cu⁺ distribution. Upon exposure to HL stimulation for 12 h, NIH-3T3 cells were treated with CuONPs or CuO@PS, both containing CuONPs at concentrations of 5 μg/mL, for 12 h, and then the cells were washed and detected with Cu⁺ probe Coppersensor-1 (CS-1, red) (5 μM; 20 min) at different time points. Lysosomes were stained with lysotracker (green). Scale bar, 10 μm.

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2024 Oct 30;25(21):11657.  [Abstract]

    Copper content was measured using Copper sensor-1 (5 μM; 30 min) and detected by fluorescence microscopy.

    Coppersensor 1 purchased from MedChemExpress. Usage Cited in: BMC Pharmacol Toxicol. 2024 Aug 21;25(1):54.  [Abstract]

    Levels of copper in cells were labeled by copper sensor-1 (5 μM; 15 min).

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    製品説明

    Coppersensor-1 (CS1) is a membrane-permeable fluorescent dye. Coppersensor-1 has a picomolar affinity for Cu+ with high selectivity over competing cellular metalions. Coppersensor-1 as a probe, can selective and sensitive detection of copper(I) ions (Cu+) in biological samples, including live cells. Coppersensor-1 can be used for the research of imaging of severe diseases such as cancer, cardiovascular disorders and neurogenerative diseases[1].

    体外実験

    Guide (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs)[1][2].
    Cell Labeling::
    1. Prepare a reagent stock solution for imaging: Prepare a 1 mM CS1 stock solution in DMSO.
    2. One day before imaging, cells are passaged and plated on 18-mm glass coverslips coated with poly-L-lysine (50 μg/mL). Adherent cells for imaging are grown to 50-80% confluency.
    3. Remove cells from incubator, and transfer one coverslip into a 35-mm Petri dish containing 3 mL PBS buffer.
    4. To the Petri dish, add 15 μL of a 1 mM CS1 stock solution to give a final dye concentration of 5 μM. Mix thoroughly.
    5. Incubate for 5-20 min in the dark at 25 or 37°C.
    6. Imageing in standard confocal microscope with 543 nm excitation.
    (CS1 can be imaged using any type of fluorescence microscope, including epifluorescence, confocal and multiphoton)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Coppersensor 1 関連抗体
    臨床実験
    分子量

    629.81

    分子式

    C30H50BF2N3S4
    Emission (Em)

    576
    Excitation (Ex)

    543
    CAS 番号
    Appearance

    Solid

    Color

    Brown to red

    SMILES

    [F-][B+3]1([N]2=C(C)C(CC)=C(C)C2=C(CN(CCSCCSCC)CCSCCSCC)C3=C(C)C(CC)=C(C)[N-]31)[F-]
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
    溶剤 & 溶解度
    体外: 

    DMSO : 25 mg/mL (39.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.5878 mL 7.9389 mL 15.8778 mL
    5 mM 0.3176 mL 1.5878 mL 3.1756 mL
    10 mM 0.1588 mL 0.7939 mL 1.5878 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

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    一般には略語で表示されます：C1V1 = C2V2

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    純度とドキュメンテーション

    純度: ≥98.0%

    COA (252 KB) HNMR (268 KB) MS (69 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.5878 mL 7.9389 mL 15.8778 mL 39.6945 mL
    5 mM 0.3176 mL 1.5878 mL 3.1756 mL 7.9389 mL
    10 mM 0.1588 mL 0.7939 mL 1.5878 mL 3.9695 mL
    15 mM 0.1059 mL 0.5293 mL 1.0585 mL 2.6463 mL
    20 mM 0.0794 mL 0.3969 mL 0.7939 mL 1.9847 mL
    25 mM 0.0635 mL 0.3176 mL 0.6351 mL 1.5878 mL
    30 mM 0.0529 mL 0.2646 mL 0.5293 mL 1.3232 mL
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    Coppersensor 1 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Coppersensor 1874748-20-6Coppersensor1Coppersensor-1Fluorescent Dyemembrane-permeableboron dipyrromethene (BODIPY)fluorescent dyebiological imagingcancercardiovascular disordersneurogenerative diseasesInhibitorinhibitorinhibit

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    製品名:
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    製品番号:
    HY-141511
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