2. Others Anti-infection
  3. Insecticide Bacterial
  4. Destruxin A

Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections.

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Destruxin A

Destruxin A 構造式

CAS 番号 : 6686-70-0

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1 mg $850 在庫あり
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Based on 1 publication(s) in Google Scholar

Destruxin A 関連抗体

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  • 生物活性

  • 純度とドキュメンテーション

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製品説明

Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections[1][2][3].

Cellular Effect
Cell Line Type Value Description References
Hep 3B2 IC50
0.1 6
Compound: 2
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
[PMID: 7623030]
Hep 3B2 IC50
0.1 6
Compound: 2
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
Antiviral activity against Hepatitis B virus infected in human Hep3B cells assessed as surface antigen production
[PMID: 7623030]
体外実験

Destruxin A (16 μg/mL; 48 h) exhibits antiproliferative activity against leukemia cell line P388[2].
Destruxin A (0.03-0.33 μg/mL; 48 h) promotes the growth of leukemia cell line P388[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Destruxin A 関連抗体
体内実験

Destruxin A (injection; 86 μM; single dose) can specifically inhibit the humoral immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

577.71

分子式

C29H47N5O7
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C1[C@]2(N(C([C@@]([H])(CC=C)OC(CCNC([C@@H](N(C([C@@]([H])(N(C([C@@]([H])(N1)[C@H](CC)C)=O)C)C(C)C)=O)C)C)=O)=O)=O)CCC2)[H]
Structure Classification
Initial Source

Metarhizium anisopliae
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 10 mg/mL (17.31 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7310 mL 8.6549 mL 17.3097 mL
5 mM 0.3462 mL 1.7310 mL 3.4619 mL
10 mM 0.1731 mL 0.8655 mL 1.7310 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション

純度: 97.92%

COA (260 KB) RP-HPLC (415 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7310 mL 8.6549 mL 17.3097 mL 43.2743 mL
5 mM 0.3462 mL 1.7310 mL 3.4619 mL 8.6549 mL
10 mM 0.1731 mL 0.8655 mL 1.7310 mL 4.3274 mL
15 mM 0.1154 mL 0.5770 mL 1.1540 mL 2.8850 mL
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Destruxin A Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Destruxin A6686-70-0InsecticideBacterialP388 cellsMetarhizium anisopliaeInhibitorinhibitorinhibit

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製品名:
Destruxin A
製品番号:
HY-N6689
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