6686-70-0
Chemical Structure
Destruxin A
- CAS No.: 6686-70-0
- Formula:C29H47N5O7
- Molecular Weight:577.71
IUPAC Name: (3S,6S,9S,16R,21aS)-16-allyl-3-((S)-sec-butyl)-6-isopropyl-5,8,9-trimethyldodecahydropyrrolo[1,2-d][1]oxa[4,7,10,13,16]pentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexaone
InChIKey: XIYSEKITPHTMJT-OCCJOITDSA-N
SMILES: O=C1[C@]2(N(C([C@@]([H])(CC=C)OC(CCNC([C@@H](N(C([C@@]([H])(N(C([C@@]([H])(N1)[C@H](CC)C)=O)C)C(C)C)=O)C)C)=O)=O)=O)CCC2)[H]
Biological Activity: Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Destruxin A | 97.42% | Destruxin A is a fungal cyclopeptide with insecticidal and antiviral activities. Destruxin A has a certain inhibitory effect on leukemia cells in vitro. Destruxin A can also specifically inhibit the innate immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections. | ||||||||||||||||||||
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References
- [1]. Gong L, et al. Gene expression profile of Bombyx mori hemocyte under the stress of destruxin A. PLoS One. 2014 May 6;9(5):e96170. [Content Brief]
- [2]. Odier F, et al. In vitro effect of fungal cyclodepsipeptides on leukemic cells: study of destruxins A, B and E. Biol Cell. 1992;74(3):267-71. [Content Brief]
- [3]. Pal S, et al. Fungal peptide Destruxin A plays a specific role in suppressing the innate immune response in Drosophila melanogaster. J Biol Chem. 2007 Mar 23;282(12):8969-77. [Content Brief]
