Destruxin B
Based on 1 publication(s) in Google Scholar
Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.
For research use only. We do not sell to patients.
- Purity: 99.35%
- CAS No.: 2503-26-6
- Formula: C32H55N5O7
- Molecular Weight:621.81
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Destruxin B
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Biological Activity
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Bcl-2 |
Caspase-3 |
Destruxin B (1-30 μM; 48 hours) inhibits cell proliferation of H1299 cells and A549 cells, with IC50s of 4.1?μM and 4.9?μM, respectively[1].
Activation of mitochondria-dependent caspase cascade plays an important role in Destruxin B (1-30 μM; 48 hours) induced apoptotic cell death in A549 cells[1].
Destruxin B (1.25-20.00 μM; 72 hours) treatment significantly inhibits HT-29 human colorectal cancer cells viability in time- and dose-dependent manners[2].
Destruxin B (10 or 20?μM; 12 and 24 hours) treatment markedly increases levels of the proapoptotic protein PUMA and reduces levels of antiapoptotic proteins Mcl-1 of A549 cells in a concentration- and time-dependent manner [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:H1299 cells
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Concentration:1, 5, 10, 20, 30 μM
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Incubation Time:48 hours
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Result:Inhibited H1299 cells proliferation of H1299 cells with an IC50 of 4.1 μM.
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Cell Line:Lung adenocarcinoma A549 cells
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Concentration:1, 5, 10, 20, 30 μM
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Incubation Time:48 hours
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Result:Induces caspase-dependent Lung adenocarcinoma A549 cells death.
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Cell Line:HT-29 human colorectal cancer cells
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Concentration:1.25, 2.50, 5.00, 10.00 and 20.00 μM
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Incubation Time:72 hours
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Result:The IC50s at 24 h, 48 h and 72h were determined as 14.97, 2.00 and 0.67 μM, respectively.
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Cell Line:A549 cells
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Concentration:10 or 20 μM
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Incubation Time:12 and 24 hours
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Result:Regulates Mcl-1 and PUMA.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Athymic female nude mice (BALB/cAnN.Cg-Foxn1nu/CrlNarl), approximately 4-5 weeks old on arrival[2]
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Dosage:Low dose (0.6 mg/kg), medium dose (3 mg/kg), high dose (15 mg/kg)
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Administration:Injection; daily; for 6 weeks
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Result:Low dose, medium dose and high dose indicated a reduction of 23.9%, 33.4% and 55.8% in mean tumor size, respectively.
Chemical Information
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CAS No. 2503-26-6
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Appearance Solid
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Molecular Weight 621.81
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Formula C32H55N5O7
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Color White to off-white
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SMILES
O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O
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Structure Classification
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Initial Source
Metarhizium anisopliae
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Neotrop Entomol
Biomass and Extracts of Metarhizium robertsii MT008 as Potential Biopesticides for Controlling the Fruit Fly Anastrepha obliqua. [Abstract]2025 Nov 27;54(1):118. PMID: 41307647
Solvent & Solubility
Ethanol : 12.5 mg/mL (20.10 mM; Need ultrasonic and warming)
DMSO : ≥ 10 mg/mL (16.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (285 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / Ethanol | 1 mM | 1.6082 mL | 8.0410 mL | 16.0821 mL | 40.2052 mL |
| 5 mM | 0.3216 mL | 1.6082 mL | 3.2164 mL | 8.0410 mL | |
| 10 mM | 0.1608 mL | 0.8041 mL | 1.6082 mL | 4.0205 mL | |
| 15 mM | 0.1072 mL | 0.5361 mL | 1.0721 mL | 2.6803 mL | |
| Ethanol | 20 mM | 0.0804 mL | 0.4021 mL | 0.8041 mL | 2.0103 mL |
Destruxin B Related Classifications
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