2503-26-6

Destruxin B Chemical Structure
2503-26-6

Chemical Structure

Destruxin B

  • CAS No.: 2503-26-6
  • Formula:C32H55N5O7
  • Molecular Weight:621.81

IUPAC Name: (3S,6S,9S,16R,21aS)-3-((S)-sec-butyl)-16-isobutyl-6-isopropyl-3,5,8,9,21a-pentamethyldodecahydropyrrolo[1,2-d][1]oxa[4,7,10,13,16]pentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexaone

InChIKey: XMKZYWLIQUJHIT-NSIJXKKGSA-N

SMILES: O=C(N[C@]([C@@H](C)CC)(C)C(N(C)[C@@H](C(C)C)C(N(C)[C@@H](C)C(NCC1)=O)=O)=O)[C@@](CCC2)(C)N2C([C@@H](CC(C)C)OC1=O)=O

Biological Activity: Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells[1]. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo[2].

Cat. No. Product Name Purity Description Pricing
HY-N6690 		Destruxin B 99.35% Destruxin B, isolated from entomopathogenic fungus Metarhizium anisopliae, is one of the cyclodepsipeptides with insecticidal and anticancer activities. Destruxin B induces apoptosis via a Bcl-2 Family-dependent mitochondrial pathway in human nonsmall cell lung cancer cells. Destruxin B significantly activates caspase-3 and reduces tumor cell proliferation through caspase-mediated apoptosis, not only in vitro but also in vivo.
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