2. Metabolic Enzyme/Protease
  3. PAI-1
  4. Diaplasinin

Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy.

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Diaplasinin

Diaplasinin Estructura química

No. CAS : 481631-45-2

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10 mM * 1 mL in DMSO
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Diaplasinin Related Antibodies

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Descripciòn

Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC50 of 295 nM. Diaplasinin has antithrombotic efficacy[1].

In Vitro

PAI-749 is a potent and selective synthetic antagonist of plasminogen activator inhibitor 1 (PAI-1) that preserved tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA) activities in the presence of PAI-1 (IC50 values, 157 and 87 nM, respectively)[2].
PAI-749 quenches the fluorescence (Fl) of fluorophore-tagged PAI-1 (PAI-NBD119) with the apparent Kd of 254 nM) and the IC50 of 140 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diaplasinin Related Antibodies
Peso molecular

501.62

Fòrmula

C32H31N5O
No. CAS
Appearance

Solid

Color

Off-white to light yellow

SMILES

CCCCCC1=C(N(C2=C1C=CC=C2)CC3=CC=CC=C3)C4=CC=C5C=C(C=CC5=C4)OCC6=NN=NN6
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 125 mg/mL (249.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9935 mL 9.9677 mL 19.9354 mL
5 mM 0.3987 mL 1.9935 mL 3.9871 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.87%

SDS (251 KB)

COA (252 KB) HNMR (299 KB) LCMS (96 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9935 mL 9.9677 mL 19.9354 mL 49.8385 mL
5 mM 0.3987 mL 1.9935 mL 3.9871 mL 9.9677 mL
10 mM 0.1994 mL 0.9968 mL 1.9935 mL 4.9839 mL
15 mM 0.1329 mL 0.6645 mL 1.3290 mL 3.3226 mL
20 mM 0.0997 mL 0.4984 mL 0.9968 mL 2.4919 mL
25 mM 0.0797 mL 0.3987 mL 0.7974 mL 1.9935 mL
30 mM 0.0665 mL 0.3323 mL 0.6645 mL 1.6613 mL
40 mM 0.0498 mL 0.2492 mL 0.4984 mL 1.2460 mL
50 mM 0.0399 mL 0.1994 mL 0.3987 mL 0.9968 mL
60 mM 0.0332 mL 0.1661 mL 0.3323 mL 0.8306 mL
80 mM 0.0249 mL 0.1246 mL 0.2492 mL 0.6230 mL
100 mM 0.0199 mL 0.0997 mL 0.1994 mL 0.4984 mL
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Diaplasinin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diaplasinin481631-45-2PAI-749PAI749PAI 749PAI-1Plasminogen activator inhibitor-1plasminogenactivatorinhibitorAntithromboticInhibitorinhibit

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Nombre del producto:
Diaplasinin
Cat. No.:
HY-122098
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