2. Disease Areas
  3. Infection
  4. Bacterial Infection
  5. Vibrio Cholerae Infection

Vibrio Cholerae Infection

Vibrio cholerae infection is caused by a gram-negative, motile bacterium commonly found in aquatic environments, leading to cholera—a severe diarrheal disease characterized by profuse watery diarrhea due to the action of cholera toxin. Transmission occurs primarily via the fecal-oral route in regions with inadequate sanitation and clean water access. Virulent strains harbor the CTXφ bacteriophage encoding the cholera toxin, which binds to GM1 gangliosides on intestinal epithelial cells, triggering massive fluid and electrolyte secretion into the intestinal lumen. The bacterium exhibits a complex life cycle involving culturable forms and viable but non-culturable (VBNC) states, with environmental factors influencing its transition between these phases. It persists in nature through biofilm formation and chitin utilization, while outer membrane vesicles aid in resisting host defenses. Only 5–10% of infected individuals develop severe symptoms, though annual estimates suggest 1.3–4.0 million cases and 21,000–143,000 deaths, predominantly in South Asia, Africa, and Latin America. Treatment relies on rehydration, antibiotics, and zinc in children, with an oral vaccine approved by the FDA in 2016. Non-cholera Vibrio species such as V. vulnificus and V. parahaemolyticus cause vibriosis, typically through consumption of raw seafood, resulting in milder gastrointestinal illness and contributing to over 80,000 cases annually in the United States alone.

Vibrio Cholerae Infection (5):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N16845
    1-O-Methylclausenolide 148763-15-9
    1-O-Methylclausenolide is a natural triterpene.
    1-O-Methylclausenolide
  • HY-183878
    Zincov 71431-46-4
    Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes.
    Zincov
  • HY-B0389F1
    FITC-D-Glucose
    FITC-D-Glucose is a fluorescently labeled glucose derivative and an orally effective bacterial metabolic activity detection probe. FITC-D-Glucose is applicable to the research of cholera.
    FITC-D-Glucose
  • HY-181824
    Cholera toxin-IN-1
    Cholera toxin-IN-1 is a potent competitive inhibitor of cholera toxin B subunit (CTB) with an IC50 value of 11.78 μM. Cholera toxin-IN-1 forms stable hydrogen bonds and hydrophobic interactions. Cholera toxin-IN-1 competitively blocks the binding of CTB to GM1 ganglioside. Cholera toxin-IN-1 can be used for the research of cholera.
    Cholera toxin-IN-1
  • HY-137744
    MANT-GppNHp 148821-01-6
    MANT-GppNHp is a competitive adenyl cyclase (AC) inhibitor. MANT-GppNHp is a fluorescently labeled GTP (HY-113225) analogue. MANT-GppNHp interacts with the hydrophobic pocket near the AC catalytic site through its MANT group, thereby directly blocking the binding of the substrate ATP. MANT-GppNHp can be used to study diseases related to the increased activity of AC (such as cholera).
    MANT-GppNHp