2. Anti-infection
  3. Bacterial
  4. Zincov

Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes.

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Zincov

Zincov Chemical Structure

CAS No. : 71431-46-4

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Zincov Related Antibodies

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Description

Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes[1][2][3][4].

In Vitro

Zincov (0-800 nM; 1 h) inhibits thermolysin-catalyzed FAGLA hydrolysis with a Ki of 180 nM at pH 7.5 and 25°C[1].
Zincov (500 μM; 30 min-3.5 h) potently attenuates HA/P-mediated degradation of occludin in MDCK-I cells[3].
Zincov (500 μM; 15 min) prevents HA/P-mediated rearrangement of ZO-1 in MDCK-I cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zincov Related Antibodies

Western Blot Analysis[3]

Cell Line: Mardin-Darby canine kidney epithelial cell line I (MDCK-I) cells
Concentration: 500 μM
Incubation Time: 30 min; 1 h; 2 h; 3.5 h
Result: Greatly attenuated the HA/P-mediated degradation of occludin (66-85 kDa) into 50 kDa and 35 kDa fragments, as shown by preservation of the full-length occludin bands and reduction in the intensity of the degradation product bands.

Immunofluorescence[3]

Cell Line: Mardin-Darby canine kidney epithelial cell line I (MDCK-I) cells
Concentration: 500 μM
Incubation Time: 15 min
Result: Prevented the HA/P-mediated rearrangement of ZO-1, maintaining ZO-1 as narrow continuous ribbons along cell-cell boundaries, similar to untreated cells.
Molecular Weight

302.33

Formula

C12H22N4O5
CAS No.
SMILES

NC(CNC([C@H](C)NC(C(CC(C)C)C(NO)=O)=O)=O)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zincov Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zincov71431-46-4BacterialVibrio choleraeThermolysinchicken erythrocytesMDCK-I cellsnormal ratstrypsinoccludinZO-1HA/proteasediabetic ratsInhibitorinhibitorinhibit

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