71431-46-4
Chemical Structure
Zincov
- CAS No.: 71431-46-4
- Formula:C12H22N4O5
- Molecular Weight:302.33
InChIKey: FGSNBBSHVNLDMX-JAMMHHFISA-N
SMILES: NC(CNC([C@H](C)NC(C(CC(C)C)C(NO)=O)=O)=O)=O
Biological Activity: Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Zincov | Zincov is an orally active hydroxamic acid derivative and bacterial metalloproteinase inhibitor. Zincov blocks chloride ion binding by binding to the active site of thermolysin, thereby inhibiting the hydrolysis and blood coagulation reactions catalyzed by this enzyme. Meanwhile, Zincov attenuates cytotoxicity, prevents protein degradation and ZO-1 rearrangement without affecting the functions of other common proteases. Zincov exhibits blood glucose-regulating and antioxidant activities; it reduces blood glucose levels and increases liver dry weight in diabetic rats, but elevates blood glucose levels in normal rats. Zincov is widely used in studies related to cholera and diabetes. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Inouye K, et al. A spectrophotometric study on the interaction of thermolysin with chloride and bromide ions, and the state of tryptophyl residue 115. J Biochem. 1994;116(3):530-535. [Content Brief]
- [2]. Booth BA, et al. Vibrio cholerae soluble hemagglutinin/protease is a metalloenzyme. Infect Immun. 1983;42(2):639-644. [Content Brief]
- [3]. Wu Z, et al. Distinct effects of Vibrio cholerae haemagglutinin/protease on the structure and localization of the tight junction-associated proteins occludin and ZO-1. Cell Microbiol. 2000;2(1):11-17. [Content Brief]
- [4]. Satyam S M, et al. Influence of Grape seed extract and Zincovit tablets (Nutritional food supplement) on glucose level in normal and streptozocin induced diabetic rats[J]. Int J Pharm Sci, 2013, 5(3): 413-416.
Keywords
