2. Anti-infection NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. Fungal Reactive Oxygen Species (ROS)
  4. Dithianon

Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.

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Dithianon

Dithianon 화학구조

CAS No. : 3347-22-6

사이즈 가격 재고 수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 해외재고보유
Solution
10 mM * 1 mL in DMSO 해외재고보유
Solid
25 mg 해외재고보유
50 mg 해외재고보유
100 mg 해외재고보유
200 mg   견적 받기  
500 mg   견적 받기  

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Other Forms of Dithianon:

Dithianon Related Antibodies

Top Publications Citing Use of Products

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  • References

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제품 설명

Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others[1][2].

IC50 & Target

Reactive oxygen species (ROS)[1]
Colletotrichum sp.; Elsinoe ampelina; Plasmopara viticola; Phomopsis viticola[1]
In Vitro

When exponentially aerobic growing cells of S. cerevisiae are submitted to acute Dithianon treatment they loss cell wall and membrane integrity, dying by necrosis, and this behavior is associated to a depletion of reduced proteic and non-proteic thiol groups. An important increase of cellular reactive oxygen species (ROS) associated to mitochondrial membrane potential modifications on Dithianon treated cells are also detected[1].
In filamentous fungus, Dithianon inhibits mycelial growth and conidial germination. Studies on Ehrlich ascites carcinoma and yeast cells showed that Dithianon inhibits respiration and fermentation affecting several thiol enzymes of the glycolytic pathway as hexokinase, phosphofructokinase, and glyceraldeyde-3-phosphate dehydrogenase[1].
Dithianon has in vitro cytotoxic effect and affect cell transforming activity of BLAB/c 3 T3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dithianon Related Antibodies
In Vivo

The activity of testosterone hydroxylase of liver microsomes derived from male mice is increased when they are treated with acute doses of Dithianon, while in females an inactivating effect is observed[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
분자량

296.32

화학식

C14H4N2O2S2
CAS No.
Appearance

Solid

Color

Brown to dark brown

SMILES

N#CC1=C(C#N)SC(C(C2=C3C=CC=C2)=O)=C(C3=O)S1
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 50 mg/mL (168.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3747 mL 16.8736 mL 33.7473 mL
5 mM 0.6749 mL 3.3747 mL 6.7495 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • 몰농도 계산기

  • 농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.3747 mL 16.8736 mL 33.7473 mL 84.3682 mL
5 mM 0.6749 mL 3.3747 mL 6.7495 mL 16.8736 mL
10 mM 0.3375 mL 1.6874 mL 3.3747 mL 8.4368 mL
15 mM 0.2250 mL 1.1249 mL 2.2498 mL 5.6245 mL
20 mM 0.1687 mL 0.8437 mL 1.6874 mL 4.2184 mL
25 mM 0.1350 mL 0.6749 mL 1.3499 mL 3.3747 mL
30 mM 0.1125 mL 0.5625 mL 1.1249 mL 2.8123 mL
40 mM 0.0844 mL 0.4218 mL 0.8437 mL 2.1092 mL
50 mM 0.0675 mL 0.3375 mL 0.6749 mL 1.6874 mL
60 mM 0.0562 mL 0.2812 mL 0.5625 mL 1.4061 mL
80 mM 0.0422 mL 0.2109 mL 0.4218 mL 1.0546 mL
100 mM 0.0337 mL 0.1687 mL 0.3375 mL 0.8437 mL
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Dithianon Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dithianon3347-22-6FungalReactive Oxygen Species (ROS)Broad-spectrumanthraquinonepesticidenecrosisROSadherencefungaldiseasesmitochondrialglycolyticInhibitorinhibitorinhibit

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상품명:
Dithianon
Cat. No.:
HY-B1975
수량:
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SAFETY DATA SHEET (SDS)

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