Donanemab (Mouse IgG2a)  (Synonyms: mE8‑IgG2a)

Donanemab (Mouse IgG2a) (mE8-IgG2a) is a mouse-derived IgG2 monoclonal antibody used in the research of Alzheimer's disease.

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Human

Donanemab (Mouse IgG2a) (12.5 mg/kg; i.p.; weekly for 3 months) lowers Aβ₄₂ in PDAPP mice^[1].
Donanemab (Mouse IgG2a) (4-12.5 mg/kg; s.c.; weekly for 6 months) shows a significant dose-dependent decrease in Aβ₄₂ in hippocampus and cortex in sixteen-month-old PDAPP mice^[1].
Donanemab (Mouse IgG2a) (i.p.) reduces Aβ plaque in a dose-dependent manner in PDAPP mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

146.3 kDa

Liquid

Colorless to light yellow

[Donanemab (Mouse IgG2a)]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Flow Cytometry analysis of HUVEC cells labelling pGlu3Aβ (red) with Donanemab (anti-pGlu3Aβ) (HY-P991045). Alexa Fluor 488-conjugated AffiniPure Goat Anti-Mouse IgG H&L (HY-P8005) at a dilution of 1/1000 was used as the secondary antibody. Blue-Mouse IgG2a kappa (HY-P99978). Black-Unlabelled control, cells without incubation with primary antibody.

• [1]. Demattos RB, et al. A plaque-specific antibody clears existing β-amyloid plaques in Alzheimer's disease mice. Neuron. 2012 Dec 6;76(5):908-20.  [Content Brief]

  [2]. Cummings J, et al. Anti-Amyloid Monoclonal Antibodies for the Treatment of Alzheimer's Disease. BioDrugs. 2024 Jan;38(1):5-22.  [Content Brief]